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Article
Open AccessPlasma metabolites and physical function in patients undergoing hemodialysis
Impaired physical function contributes to falls, fractures, and mortality among patients undergoing dialysis. Using a metabolomic approach, we identified metabolite alterations and effect size-based composite ...
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Article
Open AccessRelationship between klotho and physical function in healthy aging
Epidemiological studies have reported a strong association between circulating Klotho and physical function; however, the cohorts were comprised of older adults with multiple comorbidities. Herein, we examined...
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Article
Open AccessSkeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease
Chronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary wheel running can improve skeletal muscle mitochond...
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Bone Biology, Modeling, Remodeling, and Mineralization
The bone is a composite structure comprised primarily of mineral (hydroxyapatite) and organic matrix composed of collagen and non-collagenous proteins. Bone formation occurs through either intramembranous or e...
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Article
Open AccessEffect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats
Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features of late stage chronic kidney disease-mineral bone disorder (CKD-MBD), spe...
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Renal Osteodystrophy or Kidney-Induced Osteoporosis?
Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD relat...
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Article
Pathophysiology of Vascular Calcification
Vascular calcification can lead to cardiovascular morbidity and mortality. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The pathoge...
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Article
Chronic Kidney Disease-Mineral Bone Disorder: Definitions and Rationale for a Systemic Disorder
Over the past decade there has been an increasing awareness of the complexity of bone and mineral complications observed in chronic kidney disease (CKD) and recognition that the consequences of these abnormali...
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Vascular Calcification: Pathophysiology and Risk Factors
Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of t...
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Children with chronic kidney disease: are they insured as adults?
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Cinacalcet Hydrochloride
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Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis
Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a ...
