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Article
Open AccessCo-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance
Co-infections with different variants of SARS-CoV-2 are a key precursor to recombination events that are likely to drive SARS-CoV-2 evolution. Rapid identification of such co-infections is required to determin...
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Article
Open AccessDocumenting elimination of co-circulating COVID-19 clusters using genomics in New South Wales, Australia
To adapt ‘fishplots’ to describe real-time evolution of SARS-CoV-2 genomic clusters.
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Article
Scedosporium and Lomentospora infections in lung transplant recipients
Infections caused by uncommon or rare mould pathogens often complicate the management of lung transplant (Tx) recipients contributing to high mortality. This review explores the epidemiology, diagnosis, and ma...
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Reference Work Entry In depth
Management of Mucorales Infections in Transplant Patients
Infections due to Mucorales fungi in hematopoietic stem cell transplantation (HSCT) and solid organ transplant (SOT) recipients may be increasing. Disease is severe and rapidly progressive and carries high mor...
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Chapter
Yeast Infections
Invasive fungal disease (IFD) caused by yeast pathogens complicates both cancer chemotherapy for haematological malignancy as well autologous and allogeneic haematopoietic stem cell transplantation (HSCT). Inv...
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Article
Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling
In January 2020, a novel betacoronavirus (family Coronaviridae), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the etiological agent of a cluster of pneumonia cases occurri...
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Living Reference Work Entry In depth
Management of Mucorales Infections in Transplant Patients
Infections due to Mucorales fungi in hematopoietic stem cell transplantation (HSCT) and solid organ transplant (SOT) recipients may be increasing. Disease is severe and rapidly progressive and carries high mor...
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Article
Fungal Eye Infections: New Hosts, Novel Emerging Pathogens but No New Treatments?
We sought to explore the current incidence and associated risk factors associated with fungal eye infections. We also reviewed new diagnostic strategies and recent clinical studies exploring the use of topical...
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Article
Challenges in Laboratory Detection of Fungal Pathogens in the Airways of Cystic Fibrosis Patients
Study of the clinical significance of fungal colonization/infection in the airways of cystic fibrosis (CF) patients, especially by filamentous fungi, is challenged by the absence of standardized methodology fo...
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Article
Pseudomonas aeruginosa Inhibits the Growth of Scedosporium and Lomentospora In Vitro
In vitro bacterial–fungal interaction studies in cystic fibrosis (CF) have mainly focused on interactions between bacteria and Candida. Here we investigated the effect of Pseudomonas aeruginosa on the growth of
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Article
Antifungal Susceptibility Testing of Candida and Cryptococcus Species and Mechanisms of Resistance: Implications for Clinical Laboratories
Resistance to antifungal drugs amongst Candida species is a growing concern, and azole resistance may be emerging in Cryptococcus species. This review provides a contemporary perspective, relevant to the clinical...
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Article
Open AccessTranscriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response
Invasive fungal infections are difficult to treat. The few available antifungal drugs have problems with toxicity or efficacy, and resistance is increasing. To overcome these challenges, existing therapies may...
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Article
Epidemiology of Scedosporiosis
Infections due to Scedosporium/Pseudallescheria species are increasingly recognized in both immunocompromised and immunocompetent hosts. Patients with organ and stem cell transplants and malignancy are at high ri...
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Article
The Genus Scedosporium and Pseudallescheria: Current Challenges in Laboratory Diagnosis
Scedosporium and Pseudallescheria fungi are increasingly encountered fungal pathogens. Species identification is important as there are differences in epidemiology, virulence, and antifun...
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Article
Generalized Subcutaneous Phaeohyphomycosis Caused by Phialophora verrucosa: Report of a Case and Review of Literature
We report a case of subcutaneous phaeohyphomycosis due to Phialophora verrucosa in a 64-year-old Chinese farmer suffering from CD4+ lymphopenia. He presented with diffuse and infiltrated plaques involving the ent...
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Article
Pharmacological and Host Considerations Surrounding Dose Selection and Duration of Therapy with Echinocandins
Caspofungin, micafungin and anidulafungin are antifungal drugs with excellent safety profiles. Dosing regimens and treatment durations must be appropriate for optimal patient outcomes. Overall, factors that af...
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Article
Nocardia Infections of the Face and Neck
Involvement of the soft tissues of the face and neck by Nocardia spp. is uncommon. We review the epidemiology, clinical features, diagnosis, and management of such infections in the setting of primary cutaneous n...
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Chapter
Fungal-Derived Immune Modulating Molecules
Invasive fungal infections are an increasing clinical problem for which new therapeutic approaches are needed. Understanding the initial interaction between fungi and the host offers potential for ...
