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Scedosporium and Lomentospora infections in lung transplant recipients

  • Fungal Infections in Transplantation (S Shoham, Section Editor)
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Abstract

Purpose of Review

Infections caused by uncommon or rare mould pathogens often complicate the management of lung transplant (Tx) recipients contributing to high mortality. This review explores the epidemiology, diagnosis, and management of Scedosporium and Lomentospora (S/L) infections in lung Tx recipients as well as highlighting constraints in the current management and areas for future research.

Recent Findings

The number of reported S/L infections remains low among lung Tx recipients whilst the diagnosis and treatment of S/L infections remains challenging. The very few studies which evaluated clinical characteristics, prognostic factors and treatment outcomes of lung Tx patients with lomentosporiosis and/or scedosporiosis were limited by single-centre and observational study design.

Summary

The requirement to standardise surveillance and culture procedure for S/L infections in lung Tx remains. Better diagnostic tools and antifungal agents are needed to manage S/L infection in this patient cohort. Prospective clinical registries or online databases for lung Tx recipients with these rare mould infections are essential to refine disease management and to improve clinical outcomes in the future.

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Authors and Affiliations

  1. Faculté de médecine et pharmacie, Poitiers, France; CHU Poitiers, Service de maladies infectieuses et tropicales, Univ Poitiers, Poitiers, France; INSERM U1070, Poitiers, France

    Blandine Rammaert

  2. The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Zoe C. F. Neoh & Monica A. Slavin

  3. Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, New South Wales, Australia

    Sharon C-A. Chen

  4. The University of Sydney, Sydney, New South Wales, Australia

    Sharon C-A. Chen

  5. The National Centre for Antimicrobial Stewardship, the Peter Doherty Institute for Infections and Immunity, Parkville, Victoria, Australia

    David C. M. Kong

  6. Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

    David C. M. Kong

  7. Pharmacy Department, Ballarat Health Services, Ballarat, Victoria, Australia

    David C. M. Kong

  8. Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Monica A. Slavin

  9. Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, Victoria, Australia

    Monica A. Slavin

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  1. Blandine Rammaert
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  2. Zoe C. F. Neoh
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  3. Sharon C-A. Chen
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  5. Monica A. Slavin
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Correspondence to Monica A. Slavin.

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Conflict of Interest

BR received travel grants for conferences from Pfizer, Gilead, Shionogi, Merck/MSD, and speaker’s fees from Merck/MSD, Gilead, Pfizer, IQone. SC-AC has received untied educational grants from MSD Australia, F2G and speaker’s fees from Gilead Sciences Inc., and sits on the Antifungal Advisory Boards of MSD Australia, Gilead Sciences Inc., and F2G. DCMK has received grants from MSD and F2G. MAS has received grants from Merck, F2G and Gilead Sciences Inc. and speaker’s fees from Pfizer and Gilead Sciences Inc., and sits on a data review committee for Roche. Other author: none to declare.

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Rammaert, B., Neoh, Z.C.F., Chen, S.CA. et al. Scedosporium and Lomentospora infections in lung transplant recipients. Curr Fungal Infect Rep 15, 49–66 (2021). https://doi.org/10.1007/s12281-021-00416-8

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