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Open Accessβ-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion of beta-cell mass is able to delay or even prevent ...
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Design and in vivo activity of A3 adenosine receptor agonist prodrugs
Prodrugs (MRS7422, MRS7476) of highly selective A3 adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′ and 3′ hydroxyl groups, and the parent, active...
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Open AccessAdipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we report the novel finding t...
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A1 Adenosine Receptor Agonists, Antagonists, and Allosteric Modulators
One of the four G protein-coupled receptors for adenosine, the A1 adenosine receptors (A1AR), is widely distributed in the body and modulates numerous normal and pathological processes, through signaling pathways...
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Open AccessDynamic expression of miRNAs across immature and adult stages of the malaria mosquito Anopheles stephensi
MicroRNAs are small non-coding RNAs that are involved in various biological processes including insect development. Anopheles stephensi serves as primary vector of malaria parasite in Asia and exhibits holometabo...
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Open AccessGenetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates
Chikungunya (CHIK) is currently endemic in South and Central India and exist as co-infections with dengue in Northern India. In 2010, New Delhi witnessed an outbreak of CHIK in the months October-December. Thi...
