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Article
Open AccessCirculating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients
Among several secreted glycoproteins belonging to the thrombospondin family, thrombospondin 2 (TSP2) is involved in various functions, including collagen/fibrin formation. Liver/serum TSP2 levels have been cor...
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Article
Open AccessAdipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice
Obesity is the major driver of the global epidemic in type 2 diabetes (T2D). In individuals with obesity, impaired insulin action leads to increased lipolysis in adipocytes, resulting in elevated plasma free f...
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Article
Open Accessβ-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion of beta-cell mass is able to delay or even prevent ...
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Article
Open AccessAdipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity
Adipocyte dysfunction links obesity to insulin resistance and type 2 diabetes. Adipocyte function is regulated by receptor-mediated activation of heterotrimeric G proteins. Little is known about the potential ...
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Article
Open AccessAdipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we report the novel finding t...
