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Article
Antibacterial activity of metal–phenanthroline complexes against multidrug-resistant Irish clinical isolates: a whole genome sequencing approach
Antimicrobial resistance (AMR) is one of the serious global health challenges of our time. There is now an urgent need to develop novel therapeutic agents that can overcome AMR, preferably through alternative ...
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Article
Open AccessRe-engineering cellular physiology by rewiring high-level global regulatory genes
Knowledge of global regulatory networks has been exploited to rewire the gene control programmes of the model bacterium Salmonella enterica serovar Typhimurium. The product is an organism with competitive fitness...
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Article
Bacterial nucleoid-associated proteins, nucleoid structure and gene expression
The bacterial nucleoid is dynamic in nature and undergoes changes in its local and global structure as a result of DNA replication, DNA recombination and gene ...
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Article
The SET-domain protein superfamily: protein lysine methyltransferases
The SET-domain protein methyltransferase superfamily includes all but one of the proteins known to methylate histones on lysine. Histone methylation is important in the regulation of chromatin and gene express...
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Article
Open AccessThe Hotdog fold: wrap** up a superfamily of thioesterases and dehydratases
The Hotdog fold was initially identified in the structure of Escherichia coli FabA and subsequently in 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CBS. Since that time structural determinations ...
