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  1. Article

    Open Access

    Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

    It is essential to improve therapies for controlling excessive bleeding in patients with haemorrhagic disorders. As activated blood platelets mediate the primary response to vascular injury, we hypothesize tha...

    Lily M. Du, Paquita Nurden, Alan T. Nurden, Timothy C. Nichols in Nature Communications (2013)

  2. Article

    Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression

    The flavin-containing monooxygenases (FMOs) are important for the metabolism of numerous therapeutics and toxicants. Six mammalian FMO genes (FMO1–6) have been identified, each exhibiting developmental and tissue...

    Sevasti B Koukouritaki, Pippa Simpson, Catherine K Yeung in Pediatric Research (2002)

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    Article

    Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Regulates the Signaling Mechanism of the Rapid Nongenomic Action of Dexamethasone on Actin Cytoskeleton

    We have previously shown that dexamethasone (DEX) stimulates rapid polymerization of actin and stabilization of microfilaments in human endometrial adenocarcinoma cells. As the content of total cellular actin ...

    Sevasti B. Koukouritaki, Achille Gravanis, Dr. Christos Stournaras in Molecular Medicine (1999)