-
Article
Hyaluronic acid-based biodegradable microneedles loaded with epidermal growth factor for treatment of diabetic foot
Pain relief and effective methods of treating patients with diabetic foot wounds have yet to be established. Improved surgical treatment, other than suturing, and medical (drug) treatments, are required to add...
-
Article
Open AccessNutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2
Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine...
-
Article
Open AccessIK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene, ofd1
The cilia are microtubule-based organelles that protrude from the cell surface. Abnormalities in cilia result in various ciliopathies, including polycystic kidney disease (PKD), Bardet-Biedl syndrome (BBS), an...
-
Article
Open AccessRadotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing
Tyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether radotinib (Rb) could inhibit pulmonary fibrosis by inhibiting TK in vitro a...
-
Article
Open AccessAuthor Correction: Human eye-inspired soft optoelectronic device using high-density MoS2-graphene curved image sensor array
-
Article
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional cult...
-
Article
Open AccessDecoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior
The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via an...
-
Article
Open AccessNrf2 regulates cell motility through RhoA–ROCK1 signalling in non-small-cell lung cancer cells
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of several antioxidant and anti-inflammatory enzymes. It binds to its endogenous inhibitor Kelch-like ECH-associated protei...
-
Article
Open AccessDistribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS
Spexin (SPX) is a highly conserved neuropeptide that is widely expressed in mammalian brain and peripheral tissue. In teleost, SPX1 is mainly expressed in the brain and ovary, and is involved in reproduction a...
-
Article
Open AccessDevelopment of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis
The development of novel peptide antibiotics with potent activity against multidrug-resistant Gram-negative bacteria and anti-septic activity is urgently needed. In this study, we designed short, 12-meric anti...
-
Article
Open AccessHuman eye-inspired soft optoelectronic device using high-density MoS2-graphene curved image sensor array
Soft bioelectronic devices provide new opportunities for next-generation implantable devices owing to their soft mechanical nature that leads to minimal tissue damages and immune responses. However, a soft for...
-
Article
Open AccessNanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins
Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase com...
-
Article
Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia–Reperfusion Injury in the Gerbil Hippocampus
Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In thi...
-
Article
High-resolution three-photon biomedical imaging using doped ZnS nanocrystals
Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this proces...
-
Article
Live image profiling of neural crest lineages in zebrafish transgenic lines
Zebrafish transgenic lines are important experimental tools for lineage tracing and imaging studies. It is crucial to precisely characterize the cell lineages labeled in transgenic lines to understand their li...
-
Article
Comparison of Neurogenesis in the Dentate Gyrus Between the Adult and Aged Gerbil Following Transient Global Cerebral Ischemia
In the present study, we compared differences in cell proliferation, neuroblast differentiation and neuronal maturation in the hippocampal dentate gyrus (DG) between the adult and aged gerbil induced by 5 min ...
-
Article
FoxO3a Changes in Pyramidal Neurons and Expresses in Non-Pyramidal Neurons and Astrocytes in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia
The forkhead box O (FoxO) proteins regulate processes ranging from cell longevity to cell apoptosis and function as transcription factors. FoxO3a is expressed throughout the brain including the hippocampus. In...
-
Article
Open AccessAKAP12 regulates vascular integrity in zebrafish
The integrity of blood vessels controls vascular permeability and extravasation of blood cells, across the endothelium. Thus, the impairment of endothelial integrity leads to hemorrhage, edema, and inflammator...
-
Article
Time-Course Alterations of Toll-Like Receptor 4 and NF-κB p65, and Their Co-Expression in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia
Innate immune system is very important to modulate the host defense against a large variety of pathogens. Toll-like receptors (TLRs) play a key role in controlling innate immune response. Among TLRs, TLR4 is a...
-
Article
Na+/HCO3 − Cotransporter Immunoreactivity Changes in Neurons and Expresses in Astrocytes in the Gerbil Hippocampal CA1 Region After Ischemia/Reperfusion
The maintenance of intracellular pH is important in neuronal function. Na+/HCO3 − cotransporter (NBC), a bicarbonate-dependent acid–base transport protein, may contribute to cellular acid–...
