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Article
Urinary Symptoms and Urodynamic Findings in Patients with Spinocerebellar Ataxia
Urinary dysfunctions are not considered symptoms of spinocerebellar ataxias (SCAs). However, given that a patient with SCAs without a family history might be misdiagnosed as MSA-C when having urinary dysfuncti...
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Article
Increased Diagnostic Yield of Spastic Paraplegia with or Without Cerebellar Ataxia Through Whole-Genome Sequencing
Inherited disorders of spasticity or ataxia exist on a spectrum with overlap** causative genes and phenotypes. We investigated the use of whole-genome sequencing (WGS) to detect a genetic cause when consider...
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Article
Open AccessDevelopment of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis
The development of novel peptide antibiotics with potent activity against multidrug-resistant Gram-negative bacteria and anti-septic activity is urgently needed. In this study, we designed short, 12-meric anti...
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Article
Open AccessGranulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF
Human granulocyte colony-stimulating factor (GCSF) is a well-known cytokine for neutropenia treatment. However, daily injections are required due to the short circulating half-life of the protein. To overcome ...
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Article
Soluble expression and purification of bioactive interleukin 33 in E. coli
Interleukin-33 (IL-33) is one of the important alarmins of the immune system and possesses dual functions as an anti- or pro-inflammatory molecule. The production of this cytokine in E. coli is hampered by the in...
