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Open AccessElevated nuclear TDP-43 induces constitutive exon skip**
Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-...
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Open AccessIntercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cel...
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Open AccessCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-der...
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Open AccessA clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus
Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cy...
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Ptbp1 deletion does not induce astrocyte-to-neuron conversion
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Open AccessAmyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Amongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid...
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Open AccessCell-specific regulation of gene expression using splicing-dependent frameshifting
Precise and reliable cell-specific gene delivery remains technically challenging. Here we report a splicing-based approach for controlling gene expression whereby separate translational reading frames are coup...
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Open AccessIn vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration in children. LCA patients with RPE65 mutations show accelerated cone photoreceptor dysfunction and death, resulting in e...
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Open AccessAuthor Correction: The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
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Open AccessAuthor Correction: A potential role for somatostatin signaling in regulating retinal neurogenesis
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Open AccessA potential role for somatostatin signaling in regulating retinal neurogenesis
Neuropeptides have been reported to regulate progenitor proliferation and neurogenesis in the central nervous system. However, these studies have typically been conducted using pharmacological agents in ex viv...
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Open AccessTemperature and species-dependent regulation of browning in retrobulbar fat
Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and ...
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Open AccessGene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons
GABAergic neurons of the hypothalamus regulate many innate behaviors, but little is known about the mechanisms that control their development. We previously identified hypothalamic neurons that express the LIM...
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Open AccessThe cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
The hypothalamus is a central regulator of many innate behaviors essential for survival, but the molecular mechanisms controlling hypothalamic patterning and cell fate specification are poorly understood. To i...
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Open AccessASCOT identifies key regulators of neuronal subtype-specific splicing
Public archives of next-generation sequencing data are growing exponentially, but the difficulty of marshaling this data has led to its underutilization by scientists. Here, we present ASCOT, a resource that u...
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Winding the Clock: Development of Hypothalamic Structures Controlling Biological Timing and Sleep
The daily cycle of sleep and wake governs all aspects of behavior and is under tight homeostatic regulation. The core circadian oscillator in turn restricts sleep to specific intervals of the solar day. The ne...
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Open AccessTissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium
Accurate analysis of gene expression in human tissues using RNA sequencing is dependent on the quality of source material. One major source of variation in mRNA quality is post-mortem time. While it is known t...
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Open AccessReactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
Microglia and inflammation have context-specific impacts upon neuronal survival in different models of central nervous system (CNS) disease. Herein, we investigate how inflammatory mediators, including microgl...
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Open AccessEpigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin
Retinal neurogenesis occurs through partially overlap** temporal windows, driven by concerted actions of transcription factors which, in turn, may contribute to the establishment of divergent genetic program...
