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Article
Open AccessDeciphering the therapeutical potentials of rosmarinic acid
Lemon balm is herbal tea used for soothing stomach cramps, indigestion, and nausea. Rosmarinic acid (RA) is one of its chemical constituents known for its therapeutic potentials against cancer, inflammatory an...
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Article
Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes
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Article
CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes
In this study, the role of CX3CR1 in the progression of diabetic retinopathy (DR) was investigated. The retinas of wild-type (WT), CX3CR1 null (CX3CR1gfp/gfp, KO), and heterozygous (CX3CR1+/gfp, Het) mice were co...
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Chapter
Circulating Endothelial Progenitor Cells and Adult Vasculogenesis
Postnatal neovascularization (NV) has previously been considered synonymous with proliferation and migration of pre-existing, fully differentiated endothelial cells resident within parent vessels. The finding ...
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Chapter
Antagonism of the Growth Hormone Axis as a Therapeutic Strategy for Diabetic Retinopathy
Drugs targeting somatostatin (SST) receptors have been long recognized as having promise for treating proliferative diabetic retinopathy (PDR) by a systemic mechanism of action involving inhibition of the insu...
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Article
Generation of functional hemangioblasts from human embryonic stem cells
Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an eff...
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Protocol
Analysis of the Vascular Potential of Hematopoietic Stem Cells
The hematopoietic stem cells residing in the bone marrow have tremendous proliferative and self-renewing capacity, and until recently these cells were thought to produce only progeny of the blood lineages. We ...
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Article
Mouse models of visual deficits
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Article
The many possible roles of stem cells in age-related macular degeneration
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Chapter
The Contribution of Adult Hematopoietic Stem Cells to Retinal Neovascularization
Retinal neovascular diseases such as diabetic retinopathy and retinopathy of prematurity are among the leading causes of vision impairment throughout the world. Retinal neovascularization is thought to occur i...
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Article
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization
Adults maintain a reservoir of hematopoietic stem cells that can enter the circulation to reach organs in need of regeneration. We developed a novel model of retinal neovascularization in adult mice to examine...
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Article
Heterogeneity among macrophages cultured from mouse bone marrow
The development of macrophages in culture from mouse bone marrow was followed for 14 days by light and electron microscopy, ultrastructural cytochemistry, and flow cytometric analysis. By 10 days greater than ...
