10 Result(s)
within
Sergei L. Kosakovsky Pond
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe complete sequence and comparative analysis of ape sex chromosomes
Apes possess two sex chromosomes—the male-specific Y chromosome and the X chromosome, which is present in both males and females. The Y chromosome is crucial for male reproduction, with deletions being linked ...
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Article
Open AccessThe genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been exten...
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Article
Open AccessDetection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City
Recombination is an evolutionary process by which many pathogens generate diversity and acquire novel functions. Although a common occurrence during coronavirus replication, detection of recombination is only ...
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Article
Open AccessRapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (...
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Article
Detection of a SARS-CoV-2 variant of concern in South Africa
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (des...
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Open AccessSelection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy
Most HIV-1-infected individuals with virological failure on a pharmacologically-boosted protease inhibitor (PI) regimen do not develop PI-resistance protease mutations. One proposed explanation is that HIV-1 gag ...
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Article
Lorenzo-Redondo et al. reply
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Article
Open AccessEvolution of gag and gp41 in Patients Receiving Ritonavir-Boosted Protease Inhibitors
Several groups have proposed that genotypic determinants in gag and the gp41 cytoplasmic domain (gp41-CD) reduce protease inhibitor (PI) susceptibility without PI-resistance mutations in protease. However, no gag
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Article
Open AccessViral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection
Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape muta...
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Article
Persistent HIV-1 replication maintains the tissue reservoir during therapy
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although co...
