15 Result(s)

Article

Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4⁺ T-cells

Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmi...

Stephanie B. H. Gumbs, Arjen J. Stam, Tania Mudrikova… in Journal of NeuroVirology (2024)

Article

Subregional origins of emerging SARS-CoV-2 variants during the second pandemic wave in Côte d’Ivoire

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility, virulence and immune escape abilities have heavily altered the COVID-19 pandemic’s course. Deciphering loc...

Etilé A. Anoh, Oby Wayoro, Pacôme Monemo, Essia Belarbi, Andreas Sachse… in Virus Genes (2023)

Article

SARS-CoV-2 Africa dashboard for real-time COVID-19 information

The SARS-CoV-2 Africa dashboard is an interactive tool that enables visualization of SARS-CoV-2 genomic information in African countries. The customizable app allows users to visualize the number of sequences ...

Joicymara S. Xavier, Monika Moir, Houriiyah Tegally, Nikita Sitharam… in Nature Microbiology (2023)

Article

Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa’s fourth Coronavirus Disease 2019 (COVID-19)...

Houriiyah Tegally, Monika Moir, Josie Everatt, Marta Giovanetti… in Nature Medicine (2022)

Article

Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, but important gaps r...

Marta Giovanetti, Svetoslav Nanev Slavov, Vagner Fonseca… in Nature Microbiology (2022)

Article

Comparison of SARS-CoV-2 sequencing using the ONT GridION and the Illumina MiSeq

Over 4 million SARS-CoV-2 genomes have been sequenced globally in the past 2 years. This has been crucial in elucidating transmission chains within communities, the development of new diagnostic methods, vacci...

Derek Tshiabuila, Jennifer Giandhari, Sureshnee Pillay, Upasana Ramphal… in BMC Genomics (2022)

Article

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage

Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C...

Cathrine Scheepers, Josie Everatt, Daniel G. Amoako… in Nature Communications (2022)

Article

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (...

Raquel Viana, Sikhulile Moyo, Daniel G. Amoako, Houriiyah Tegally… in Nature (2022)

Article

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations^1,2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-CoV-2³. Here, using a live-virus ...

Sandile Cele, Inbal Gazy, Laurelle Jackson, Shi-Hsia Hwa, Houriiyah Tegally… in Nature (2021)

Article

SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy

We investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulatio...

Marta Giovanetti, Eleonora Cella, Francesca Benedetti… in Communications Biology (2021)

Article

Detection of a SARS-CoV-2 variant of concern in South Africa

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus^1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (des...

Houriiyah Tegally, Eduan Wilkinson, Marta Giovanetti, Arash Iranzadeh… in Nature (2021)

Article

Sixteen novel lineages of SARS-CoV-2 in South Africa

The first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South Africa was identified on 5 March 2020, and by 26 March the country was in full lockdown (Oxford stringency index of 90)¹. ...

Houriiyah Tegally, Eduan Wilkinson, Richard J. Lessells… in Nature Medicine (2021)

Article

The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis

The epidemic in South Africa is characterized by high genetic diversity driven by multiple independent introductions. The bulk of these introductions occurred between 1985–2000 during which time HIV prevalence...

Eduan Wilkinson, Dennis Maletich Junqueira, Richard Lessells… in Scientific Reports (2019)

Article

History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region

HIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have d...

Eduan Wilkinson, Susan Engelbrecht, Tulio de Oliveira in Scientific Reports (2015)

Article

Diversity and molecular epidemiology of HIV-1 in Cape Town; 1984 to 2010

Susan Engelbrecht, Eduan Wilkinson, Tulio de Oliveira in Retrovirology (2011)