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Article
Open AccessLactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV, but the biological mechanisms involved remain poorly defined....
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Article
Open AccessCorrection to: Microbial function and genital inflammation in young South African women at high risk of HIV infection
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Article
Open AccessRapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (...
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Article
Detection of a SARS-CoV-2 variant of concern in South Africa
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (des...
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Article
Open AccessMicrobial function and genital inflammation in young South African women at high risk of HIV infection
Female genital tract (FGT) inflammation is an important risk factor for HIV acquisition. The FGT microbiome is closely associated with inflammatory profile; however, the relative importance of microbial activi...
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Bacterial Pan-Genomics
Due to their tendency to have a high recombination rate, bacterial genomes are highly diverse across different strains. This diversity may even be in the form of the presence or absence of entire genes; theref...