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Article
The sinking platform test: a novel paradigm to measure persistence in animal models
Persistence is the propensity to maintain goal-directed actions despite adversities. While this temperamental trait is crucial to mitigate depression risk, its neurobiological foundations remain elusive. Devel...
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Article
Open AccessAllopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of...
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Article
Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice
Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosine 5′-triphosphate (ATP). Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brain, ...
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Article
Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice
Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). In humans and mice, total MAO-A deficiency results in high 5-HT and NE leve...
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Article
Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice
Monoamine oxidase (MAO) B catalyzes the degradation of β-phenylethylamine (PEA), a trace amine neurotransmitter implicated in mood regulation. Although several studies have shown an association between low MAO B ...
