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Article
The sinking platform test: a novel paradigm to measure persistence in animal models
Persistence is the propensity to maintain goal-directed actions despite adversities. While this temperamental trait is crucial to mitigate depression risk, its neurobiological foundations remain elusive. Devel...
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Article
Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals
Antisocial behavior (ASB) is characterized by frequent violations of the rights and properties of others, as well as aggressive conduct. While ample evidence points to a critical role of serotonin in the emoti...
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Article
Open AccessTargeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences
The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in...