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Open AccessSARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was reported to alter several cellular pathwa...
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Open AccessDNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metab...
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Open AccessCorrection: Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
Nature Communications 8: Article number: 13980 (2017); Published: 27 February 2017; Updated: 13 April 2017 In Supplementary Fig. 3d, the two columns of DAPI images associated with pATM and pS/TQ images were in...
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Open AccessDNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
The DNA damage response (DDR) is a set of cellular events that follows the generation of DNA damage. Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNAs), have been show...
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Open AccessAltered expression of antioxidant enzymes and autophagic proteins in transglutaminase 2 knockout mice
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Open AccessAge-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease, especially affecting the hippocampus. Impairment of cognitive and memory functions is associated with amyloid β-peptide-induced oxidative st...
