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Article
Open AccessOrthogonal analysis of mitochondrial function in Parkinson’s disease patients
The etiopathology of Parkinson’s disease has been associated with mitochondrial defects at genetic, laboratory, epidemiological, and clinical levels. These converging lines of evidence suggest that mitochondri...
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Article
Ni/Co bimetallic flower-like metal–organic frameworks with enhanced performance for high-power energy storage applications
Metal–organic frameworks (MOFs) are promising materials for supercapacitors due to their surface area and tunable pore size. Pristine monometallic MOFs suffer from low conductivity. In this work, bimetallic Ni...
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Article
Polymorphic quantification of dexketoprofen trometamol by differential scanning calorimetry
The check of the solid phase in which the active principles crystallize is an activity of primary importance, both in the preformulation studies and in the quality control of pharmaceutical products. Indeed, i...
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Article
Open AccessThe role of muscle mass in vascular remodeling: insights from a single-leg amputee model
Both muscle mass and physical activity are independent mechanisms that play a role in vascular remodeling, however, the direct impact of muscle mass on the structure and function of the vessels is not clear. T...
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Article
Open AccessRecovery, Purification, Analysis and Chemical Modification of a Waste Cooking Oil
Disposing of residual cooking oil is a major environmental concern, so its conversion into commercial products is a desirable goal. To design the chemical modification of a domestic waste oil into valuable bio...
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Article
The clinical perfectionism questionnaire: psychometric properties of the Italian version in patients with eating disorders
Problematic perfectionism has been traditionally conceptualized as a multidimensional construct, and specific instruments have been developed to capture its various dimensions. However, the Clinical Perfection...
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Article
Validity and reliability of the Dietary Rules Inventory (DRI)
Dietary rules are common in patients with eating disorders, and according to transdiagnostic cognitive behavioural theory for eating disorders, represent a key behaviour maintaining eating-disorder psychopatho...
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Article
Knee flexor and extensor torque ratio in elderly men and women with and without obesity: a cross-sectional study
With aging and obesity lower limb torque deteriorates. Importantly, the ratio between knee flexor (KF) and extensor (KE) torque is an indicator of joint stability.
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Article
Probenecid and benzamide: DSC applied to the study of an “impossible” pharmaceutical system
The study of the binary system probenecid–benzamide is an excellent example of the power and the limits of thermal analysis applied to the investigations of compounds of pharmaceutical interest. The DSC curves...
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Article
Open AccessGender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease
Alterations in the metabolism of iron and its accumulation in the substantia nigra pars compacta accompany the pathogenesis of Parkinson’s disease (PD). Changes in iron homeostasis also occur during aging, which ...
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Article
Open AccessInside the failure mechanism of tin oxide as anode for sodium ion batteries
The conversion-alloying compounds have been identified as promising anode materials for sodium ion batteries (SIBs). One of them, SnO2, with an enormous theoretical capacity of 1558 mAh g−1 is an interesting cand...
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Article
Full characterisation of knee extensors’ function in ageing: effect of sex and obesity
Muscle function is a marker of current and prospective health/independence throughout life. The effects of sex and obesity (OB) on the loss of muscle function in ageing remain unresolved, with important implic...
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Article
Probenecid and benzamide: cocrystal prepared by a green method and its physico-chemical and pharmaceutical characterization
The eco-friendly method of kneading was here used to synthesize a cocrystal of probenecid, an uricosuric drug used in treating gout and hyperuricemia, with the aim to improve its pharmaceutical behavior. Benza...
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Article
Bone and skeletal muscle changes in oldest-old women: the role of physical inactivity
Alterations in bone and muscle parameters related to advanced aging and physical inactivity have never been investigated in oldest-old women.
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Article
Open AccessDNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metab...
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Article
Physico-chemical and pharmaceutical characterization of sulindac–proglumide binary system
Sulindac is a nonsteroidal anti-inflammatory drug with poor water solubility. This study presents a way to increase its dissolution rate while reducing the risk of gastrointestinal side effects. This approach ...
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Article
Silica-supported pyrolyzed lignin for solid-phase extraction of rare earth elements from fresh and sea waters followed by ICP-MS detection
Silica-supported pyrolyzed lignin (pLG@silica) was investigated as a solid sorbent for the pre-concentration of rare earth elements (REE) from natural waters followed by inductively coupled plasma mass spectro...
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Article
The clinical impairment assessment questionnaire: validation in Italian patients with eating disorders
The Clinical Impairment Assessment (CIA) is a measure of functional impairment secondary to eating disorder symptoms.
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Article
Open AccessActivation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease
The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into th...
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Article
Synthesis and characterization of LaFeO3 powders prepared by a mixed mechanical/thermal processing route
Lanthanum ferrite, LaFeO3 (LF), has raised considerable interest since it can be used in many applications such as solid-oxide fuel cell electrode, sensor material (H2O and ethanol) and catalyst. Since the conven...
