10 Result(s)
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Sanjeev A. Vasudevan
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Article
Open AccessA humanized mouse model for adeno-associated viral gene therapy
Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver ch...
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Article
Open AccessAuthor Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
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Article
Open AccessRestoration of the molecular clock is tumor suppressive in neuroblastoma
MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression of the main re...
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Article
Open AccessMDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to...
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Surgical Strategies for High Risk Neuroblastoma
The surgical management of high risk neuroblastoma has been highly debated over the last decade. Many surgeons attempt a near total resection of the tumor no matter how extensive, and others believe that parti...
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Article
Open AccessA Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma
Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized th...
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Open AccessWip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis
Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a relatively low frequency in NB and the downstream fun...
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Article
mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to c...
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Relapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging
Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer.
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Article
TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy
Treatment failure in high risk neuroblastoma is largely due to development of chemoresistance. NF-κB activation is one of the resistance mechanisms for cancer cells to escape from chemotherapy-induced cell-dea...
