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    Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

    Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

    Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)