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Article
Fluorocarbon Emulsions as a Blood Substitute
In 1966 CLARK discovered that animals breathing certain perfluorinated liquids can transfer enough oxygen and carbon dioxide to sustain life [Science 152: 1755, 1966]. This suggested that these liquids may serve ...
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Article
Echocardiography in the diagnosis of neonatal congenital heart disease
Since its introduction in 1954, diagnostic ultrasound has been used to record the movement of atrio-ventricular valves, to measure atrial and ventricular dimensions, left venticular free wall thickness, left v...
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Article
ECHOCARDIOGRAPHIC ASSESSMENT OF PATENT DUCTUS ARTERIOSOS IN PREMATURES WITH RESPIRATORY DISTRESS
Non-invasive evaluation of significant left to right shunting through a patent ductus arteriosus (PDA) is difficult in premature infants with respiratory distress. Sixteen infants (gestation 26-36 weeks; weigh...
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Article
NON-INVASIVE RIGHT AND LEFT SYSTOLIC TIME INTERVALS BY ECHOCARDIOGRAPHY
Evaluation of left ventricular performance has been possible by the measurement of systolic time intervals (STI's). However non-invasive assessment of right ventricular performance has been difficult because i...
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Article
NON-INVASIVE ESTIMATION OF LEFT TO RIGHT SHUNTS USING ECHOCARDIOGRAMS AND RADIONUCLIDE ANGIOCARDIOGRAPHY
Echocardtography (echo) has been used in children with ventricular septal defects (VSD) to estimate the magnitude of left to right shunt (Qp/Qs) and has been correlated with Qp/Qs measured by Fick method using...
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Article
SPECTRUM OF EXERCISE RESPONSES IN CHILDREN WITH AORTIC STENOSIS
Significant abnormalities in cardiovascular dynamics may occur during exercise (Ex) in patients (P) with aortic stenosis (AS). This study was designed to record systolic pressure (ESP), electrocardiogram (ECG)...
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Article
212 MYOCARDIAL PERFUSION DURING EXERCISE IN DOGS WITH LEFT VENTRICULAR OBSTRUCTION ABOVE AND BELOW CORONARY ARTERIES
Strenuous exercise is thought to induce global myocardial ischemia in the presence of left ventricular hypertrophy (LVH) and normal coronary arteries. Myocardial perfusion (MBF) and cardiac index (CI) were mea...
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Article
183 “RESPIRATOR PARADOX” IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME
Eleven premature infants (28-32 wks gestation; 900-1400 grams) had echocardiograms performed during the first week of life. Left ventricular (LV) pre-ejection periods (PEP) and ejection times (ET) were measure...
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Article
THE SPECTRUM OF PULMONARY VASCULAR DISEASE IN INFANTS AND CHILDREN WITH CARDIOMYOPATHY
The presence of pulmonary vascular disease (PVD) in patients undergoing cardiac transplantation may result in death from acute right ventricular failure. This study was undertaken to explore the frequency and ...
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Article
NORMALIZATION OF PLASMA NOREPINEPHRINE FOLLOWING REPAIR OF INTRACARDIAC LEFT TO RIGHT SHUNTS
Plasma norepinephrine (PNE) is elevated in patients with conogestive heart failure (CHF) and the degree of elevation corresponds to the severity of the CHF. This study was performed to determine whether PNE re...
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Article
CHARACTERIZATION OF THE QT INTERVAL DURING UPRIGHT EXERCISE IN CHILDREN
The QTc interval which reflects ventricular activation/repolarization has not been characterized in children during exercise. We studied 60 children (ages 5-18 years) who underwent upright cycle ergometry accordi...
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Article
CHILDREN WITH COMPENSATED AORTIC STENOSIS MAINTAIN ENHANCED EJECTION PERFORMANCE DURING EXERCISE
It has been shown that ejection phase indices are elevated in children with aortic stenosis (AS) at rest. We performed two-dimensional and M-mode echocardiography in 14 patients with AS and in 7 normal (NL) ch...
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Article
ABNORMALITIES IN VENTRICULAR ACTIVATION AND REPOLARIZATION IN SICKLE CELL DISEASE AND NORMAL SIBLINGS
Prolongation of the QTc interval can result from lengthening of ventricular activation and/or repolarization due to ischemia. Although we have previously reported exercise induced ischemic-like ST depression in c...
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Article
Laboratory Diagnosis of Central Nervous System Infection
Central nervous system (CNS) infections are potentially life threatening if not diagnosed and treated early. The initial clinical presentations of many CNS infections are non-specific, making a definitive etio...