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Article
Perfluorooctylbromide (PFOB) as a vitreous substitute in non-human primates
We evaluated the toxicity of perfluorooctylbromide in the primate eye as a short-term postoperative vitreous substitute. Four eyes of 4 African green monkeys underwent complete vitrectomy and vitreous replacem...
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Chapter
The Nature of Fluorocarbon Enhanced Cerebral Oxygen Transport
This brief communication is intended to epitomize our on-going research relating blood and brain fluorocarbon levels to Polarographic oxygen availability (aO2) as recorded from healed platinum electrodes in the b...
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Article
Physiological Evaluation of Fluorocarbon Emulsions with Notes on F-Decalin and Pulmonary Inflation in the Rabbit
Continuing refinement of fluorocarbon blood substitutes depends upon perfection and application of methods to monitor oxygen transport in living animals. Methods involving chronic catheterization, electrode im...
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Chapter
Perfluorinated Organic Liquids and Emulsions as Biocompatible NMR Imaging Agents for 19F and Dissolved Oxygen
Emulsions of fluorocarbons are finding considerable use in biology for intravascular oxygen transport. Their wide clinical application seems inminent (1). Because of their high content of the natural isotope o...
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Chapter
Recent Advances in the Preparation and Use of Perfluorodecalin Emulsions for Tissue Perfusion
At the present time there are no perfusion media, aside from those containing red blood cells, which carry sufficient oxygen to maintain organs having a high QO2. Resort is made to hypothermia, hyperbaria, and pe...
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Chapter
Differential Anodic Enzyme Polarography for the Measurement of Glucose
The coupling of enzymes to polarographic and other electrochemical sensors has been a happy one (1–7). The first such union occurred in 1962 (8). The electrochemistry involved lends simplicity to the detecting...
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Article
Fluorocarbon Emulsions as a Blood Substitute
In 1966 CLARK discovered that animals breathing certain perfluorinated liquids can transfer enough oxygen and carbon dioxide to sustain life [Science 152: 1755, 1966]. This suggested that these liquids may serve ...
