108 Result(s)
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Salvatore Cuzzocrea
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Retraction Note: Glycogen synthase kinase-3β inhibition attenuates the development of ischaemia/reperfusion injury of the gut
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Open AccessCorrection: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
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Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
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Retraction Note To: The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury
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Editorial Expression of Concern: Hyperbaric oxygen therapy reduces the toll-like receptor signaling pathway in multiple organ failures
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Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated by an interdependent network of proinflammatory molecules such as chemokines. Prokineticin 2 (PK2) is a chemokine-like peptide that modulate...
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Open AccessTrehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis
Spinal cord injury (SCI) leads to long-term and permanent motor dysfunctions, and nervous system abnormalities. Injury to the spinal cord triggers a signaling cascade that results in activation of the inflamma...
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Open AccessEffect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis
Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by a malodorous discharge and irritation. The imbalance of the vaginal microbiota plays a key role in the development of BV. It has been demons...
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The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors
play a central role in cancers, including those (CNS). Currently, classification , especially regarding gliomas, is established on and the presence of co-deletion 1p/19q. Treatment, in most , is...
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Open AccessAçai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways
The current pharmacological treatment for Parkinson’s disease (PD) is focused on symptom alleviation rather than disease prevention. In this study, we look at a new strategy to neuroprotection that focuses on ...
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Open AccessProtective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cel...
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Neuroinflammation and Chronic Pelvic Pain Syndrome
Chronic pain is partially sustained by central sensitization, a synaptic plasticity phenomenon, and enhanced neuronal responsiveness following painful insults in the central pain pathways. Accumulating studies...
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Open AccessLoading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome
Bronchiolitis Obliterans Syndrome seriously reduces long-term survival of lung transplanted patients. Up to now there is no effective therapy once BOS is established. Nanomedicine introduces the possibility to...
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Open AccessAdenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury
Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against se...
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Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is increased in inflammatory bowel disease (IBD) patients, and its serum levels correlate with a worse prognosis. In the present manuscript, we sho...
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Open AccessDimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Oxidative stress and inflammatory pathways are involved in migraine and endogenous antioxidant defense system has a role in the prevention of hyperalgesia in migraine. In this study, we aimed to evaluate the r...
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Open AccessN-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice
Leishmaniasis is a emergent disease characterized by different clinical manifestations in both humans and dogs. Predominant clinical features of cutaneous leishmaniasis are ulcerative painless skin lesions. Se...
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Open AccessSafety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain
Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this det...
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International multicenter randomized, placebo-controlled phase III clinical trial of β-d-mannuronic acid in rheumatoid arthritis patients
The oral administration of drug β-d-mannuronic acid (M2000) showed a potent therapeutic effect in phase I/II study in rheumatoid arthritis (RA) patients. Here, our aim is to assess the efficacy and safety of this...
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2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease
Current pharmacological management of Parkinson disease (PD) does not provide for disease modification, but addresses only symptomatic features. Here, we explore a new approach to neuroprotection based on the ...
