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Open AccessCorrection: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
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Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
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Retraction Note To: The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury
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Open AccessProlyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro
Pulmonary fibrosis is a progressive disease characterized by lung remodeling due to excessive deposition of extracellular matrix. Although the etiology remains unknown, aberrant angiogenesis and inflammation p...
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Open AccessNeuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal neurons, which causes disabling motor disorders. Scientific findings support the role of epigenetics mechanism in the...
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Open AccessTrehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis
Spinal cord injury (SCI) leads to long-term and permanent motor dysfunctions, and nervous system abnormalities. Injury to the spinal cord triggers a signaling cascade that results in activation of the inflamma...
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Open AccessEffect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis
Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by a malodorous discharge and irritation. The imbalance of the vaginal microbiota plays a key role in the development of BV. It has been demons...
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The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors
play a central role in cancers, including those (CNS). Currently, classification , especially regarding gliomas, is established on and the presence of co-deletion 1p/19q. Treatment, in most , is...
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Open AccessSUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. PD etiopathogenesis is multifactorial and not yet fully known, however, the scientific world advised the establishment of neuroin...
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Role of ABT888, a Novel Poly(ADP-Ribose) Polymerase (PARP) Inhibitor in Countering Autophagy and Apoptotic Processes Associated to Spinal Cord Injury
Accidents are the cause of some 50 deaths per 100,000 population each year; some 3% of these are from traumatic spinal cord injury (SCI), a damage that causes temporary or permanent motor deficits, often leadi...
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Open AccessDimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Oxidative stress and inflammatory pathways are involved in migraine and endogenous antioxidant defense system has a role in the prevention of hyperalgesia in migraine. In this study, we aimed to evaluate the r...
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Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH)
To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigat...
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Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson’s Disease
Parkinson’s disease (PD) is a disorder caused by degeneration of dopaminergic neurons. At the moment, there is no cure. Recent studies have shown that autophagy may have a protective function against the advan...
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An In Vivo Compression Model of Spinal Cord Injury
Animal spinal cord injury (SCI) models have proven highly useful for investigating the mechanisms involved in the injury process and evaluating the effectiveness of experimental therapeutic interventions. Over...
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KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice
Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal–lysosomal pathway. This mechanism plays an important role in homeostasis and it is defect...
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Open AccessRETRACTED ARTICLE: The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury
Spinal cord injury (SCI) is a devastating condition of the central nervous system (CNS) often resulting in severe functional impairment and for which there are not yet restorative therapies. In the present stu...
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Open AccessErratum to: A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
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Open AccessHydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
Traumatic brain injury (TBI) induces secondary injury mechanisms, including dynamic interplay between ischemic, inflammatory and cytotoxic processes. We recently reported that administration of ATB-346 (2-(6-m...
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Open AccessDocosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies
Two families of polyunsaturated fatty acid (PUFA), omega-3 (ω-3) and omega-6 (ω-6), are required for physiological functions. The long chain ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA...
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Open AccessA new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
It has recently been demonstrated that palmitoylethanolamide (PEA), an endogenous lipid amide belonging to the N-acylethanolamine family, exerts neuroprotection in central nervous system (CNS) pathologies. In rec...
