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Article
Open AccessTumor biomechanics as a novel imaging biomarker to assess response to immunotherapy in a murine glioma model
Glioblastoma is the most common and aggressive primary malignant brain tumor with poor prognosis. Novel immunotherapeutic approaches are currently under investigation. Even though magnetic resonance imaging (M...
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Article
Open AccessDiffusion tensor imaging in anisotropic tissues: application of reduced gradient vector schemes in peripheral nerves
In contrast to the brain, fibers within peripheral nerves have distinct monodirectional structure questioning the necessity of complex multidirectional gradient vector schemes for DTI. This proof-of-concept st...
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Article
Open AccessAssociation of Small Fiber Function with Microvascular Perfusion of Peripheral Nerves in Patients with Type 2 Diabetes
Diabetic small fiber neuropathy (SFN) is caused by damage to thinly myelinated A‑fibers (δ) and unmyelinated C‑fibers. This study aimed to assess associations between quantitative sensory testing (QST) and par...
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Article
Open AccessIatrogenic Air Embolisms During Endovascular Interventions: Impact of Origin and Number of Air Bubbles on Cerebral Infarctions
Cerebral infarctions caused by air embolisms (AE) are a feared risk in endovascular procedures; however, the relevance and pathophysiology of these AEs is still largely unclear. The objective of this study was...
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Article
Open AccessA diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes
Quantitative sensory testing (QST) allows the identification of individuals with rapid progression of diabetic sensorimotor polyneuropathy (DSPN) based on certain sensory phenotypes. Hence, the aim of this stu...
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Article
Open AccessMagnetization transfer ratio of the sciatic nerve differs between patients in type 1 and type 2 diabetes
Previous studies on magnetic resonance neurography (MRN) found different patterns of structural nerve damage in type 1 diabetes (T1D) and type 2 diabetes (T2D). Magnetization transfer ratio (MTR) is a quantita...
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Article
Open AccessAn AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids
Cerebral organoids recapitulate the structure and function of the develo** human brain in vitro, offering a large potential for personalized therapeutic strategies. The enormous growth of this research area ove...
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Article
Open AccessQuantification and Proximal-to-Distal Distribution Pattern of Tibial Nerve Lesions in Relapsing-Remitting Multiple Sclerosis
Recent studies suggest an involvement of the peripheral nervous system (PNS) in multiple sclerosis (MS). Here, we characterize the proximal-to-distal distribution pattern of peripheral nerve lesions in relapsi...
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Article
Open AccessDeep Grey Matter Volume is Reduced in Amateur Boxers as Compared to Healthy Age-matched Controls
Mild traumatic brain injuries (mTBI) sustained during contact sports like amateur boxing are found to have long-term sequelae, being linked to an increased risk of develo** neurological conditions like Parki...
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Article
Open AccessDiagnostic compatibility of various fixed orthodontic retainers for head/neck MRI and dental MRI
To evaluate the diagnostic MRI compatibility of different fixed orthodontic retainers using a high-resolution 3D-sequence optimized for artifact reduction.
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Article
Open AccessT cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Glioblastoma, the most common and aggressive primary brain tumor type, is considered an immunologically “cold” tumor with sparse infiltration by adaptive immune cells. Immunosuppressive tumor-associated myeloi...
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Article
Open AccessEndodontic working length measurements of premolars and molars in high-resolution dental MRI: a clinical pilot study for assessment of reliability and accuracy
To prospectively assess the reliability and accuracy of high-resolution, dental MRI (dMRI) for endodontic working length (WL) measurements of premolars and molars under clinical conditions.
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Article
Open AccessReliability and accuracy of dental MRI for measuring root canal length of incisors and canines: a clinical pilot study
To evaluate whether high-resolution, non-contrast-enhanced dental MRI (dMRI) can reliably and accurately measure the canal length of incisors and canines compared with cone-beam computed tomography (CBCT). Thr...
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Article
Open AccessNeurofilament light chain plasma levels are associated with area of brain damage in experimental cerebral malaria
Neurofilament light chain (NfL), released during central nervous injury, has evolved as a powerful serum marker of disease severity in many neurological disorders, including infectious diseases. So far NfL has...
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Article
Open AccessMagnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle
To assess the correlation of peripheral nerve and skeletal muscle magnetization transfer ratio (MTR) with demographic variables.
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Article
Open AccessLong-term Follow-up and Histological Correlation of Peripheral Nervous System Alterations in Neurofibromatosis Type 2
To examine long-term alterations of the dorsal root ganglia (DRG) and the peripheral nerve in patients with neurofibromatosis type 2 (NF2) by in vivo high-resolution magnetic resonance neurography (MRN) and th...
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Article
Open AccessReliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry
To assess the interreader and test-retest reliability of magnetization transfer imaging (MTI) and T2 relaxometry in sciatic nerve MR neurography (MRN).
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Article
Open AccessExposure to 16 h of normobaric hypoxia induces ionic edema in the healthy brain
Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, stroke, or traumatic brain injury, cerebral edema can develop. The exact nature and genesis of hypoxia-induced e...
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Article
Open AccessCombined Perfusion and Permeability Imaging Reveals Different Pathophysiologic Tissue Responses After Successful Thrombectomy
Despite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast...
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Article
Open AccessTryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate...
