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  1. Article

    Open Access

    Exposure to 16 h of normobaric hypoxia induces ionic edema in the healthy brain

    Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, stroke, or traumatic brain injury, cerebral edema can develop. The exact nature and genesis of hypoxia-induced e...

    Armin Biller, Stephanie Badde, Andreas Heckel, Philipp Guericke… in Nature Communications (2021)

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  2. Article

    Open Access

    Sodium MRI in Multiple Sclerosis is Compatible with Intracellular Sodium Accumulation and Inflammation-Induced Hyper-Cellularity of Acute Brain Lesions

    The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has no specific conventional MRI correlates. Clinicians therefore stipulate improved imaging specificity to define the pathologica...

    Armin Biller, Isabella Pflugmann, Stephanie Badde, Ricarda Diem… in Scientific Reports (2016)

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  3. Article

    Open Access

    Virtual Raters for Reproducible and Objective Assessments in Radiology

    Volumetric measurements in radiologic images are important for monitoring tumor growth and treatment response. To make these more reproducible and objective we introduce the concept of virtual raters (VRs). A ...

    Jens Kleesiek, Jens Petersen, Markus Döring, Klaus Maier-Hein… in Scientific Reports (2016)

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  4. No Access

    Chapter and Conference Paper

    Crutchfield Information Metric: A Valid Tool for Quality Control of Multiparametric MRI Data?

    We propose an information theoretic framework to automatically infer the physical relationship and asses the quality of multiparametric MRI sequences. The method is based on the Crutchfield information metric....

    Jens Kleesiek, Armin Biller… in Biomedical Engineering Systems and Technol… (2015)