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  1. No Access

    Article

    Ring-substituted analogs of 3,3′-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and –independent prostate cancer cells

    We recently reported that novel ring-substituted analogs of 3,3′-diindolylmethane (ring-DIMs) have anti-androgenic and growth inhibitory effects in androgen-dependent prostate cancer cells. The objectives of t...

    A. A. Goldberg, V. I. Titorenko, A. Beach, K. Abdelbaqi… in Investigational New Drugs (2014)

  2. No Access

    Article

    HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer

    HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver cancer patien...

    K Kim, I Jutooru, G Chadalapaka, G Johnson, J Frank, R Burghardt, S Kim, S Safe in Oncogene (2013)

  3. Article

    Erratum: The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

    Correction to: Oncogene (2012) 31, 3265–3276; doi:10.1038/onc.2011.504; published online 14 November 2011 Since the publication of the above manuscript the authors have identified an error in the author list; ...

    S-O Lee, T Andey, U-H **, K Kim, M Singh, S Safe in Oncogene (2012)

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    Article

    The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

    The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell ...

    S-O Lee, T Andey, U-H **, K Kim, M Sachdeva, S Safe in Oncogene (2012)

  5. No Access

    Article

    Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

    The human POK family members are transcription factors with a POZ domain and zinc-fingers that act primarily as transcriptional repressors. Several members of this family are involved in oncogenesis and this p...

    K Kim, G Chadalapaka, S-O Lee, D Yamada, X Sastre-Garau, P-A Defossez, Y-Y Park… in Oncogene (2012)

  6. No Access

    Chapter and Conference Paper

    Der Arylhydrocarbon Rezeptor als neue Zielscheibe zur Behandlung des Pankreaskarzinoms

    The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzo...

    Dr. med. J. Kleeff, H. Friess, A. Koliopanos, S. Safe… in Chirurgisches Forum 2002 (2002)

  7. No Access

    Article

    Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells

    Purpose: 1,3,6,8-Substituted alkyl polychlorinated dibenzofurans (PCDFs), typified by 6-methyl-1,3,8-triCDF (MCDF), inhibit 17β-estradiol (E2)-induced responses in the rodent uterus and human breast cancer cells...

    Gulan Sun, S. Safe in Cancer Chemotherapy and Pharmacology (1997)