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Article
Acute leukoencephalopathy and thyroiditis induced by capecitabine
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Article
Open AccessBayesian strategy selection identifies optimal solutions to complex problems using an example from GP prescribing
Complex health problems require multi-strategy, multi-target interventions. We present a method that uses machine learning techniques to choose optimal interventions from a set of possible interventions within...
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Article
Infektiöse Endokarditis
Trotz der Fortschritte in Diagnostik und Therapie ist die infektiöse Endokarditis (IE) noch immer eine vital bedrohliche Erkrankung mit hoher Komplikations- und Mortalitätsrate. Aufgrund der vergleichsweise ni...
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Article
Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort
Obesity and diabetes rates are high in Native Hawaiians (NHs) who commonly have mixed ancestries. People of Asian ancestry experience a high risk of type 2 diabetes despite the relatively low body weight. We e...
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Article
Impact of the cryopreservation technique and vascular bed on ovarian tissue transplantation in cynomolgus monkeys
The aim of this study was to determine the best combination in terms of cryopreservation techniques and vascular bed preparation before grafting in order to obtain functional ovarian tissue after transplantation.
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Article
Erratum: Association between erythrocyte membrane fatty acids and biomarkers of dyslipidemia in the EPIC-Potsdam study
Correction to: European Journal of Clinical Nutrition (2014) 68, 517–525; doi:10.1038/ejcn.2014.18; published online 26 February 2014 Since publication, the authors have found an SAS coding error in the LDL-ch...
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Article
Open AccessLinking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study
It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness...
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Article
Association between erythrocyte membrane fatty acids and biomarkers of dyslipidemia in the EPIC-Potsdam study
Blood proportions of fatty acids (FAs) and FA-ratios reflecting desaturase activity are associated with the risk of chronic diseases like type 2 diabetes mellitus or cardiovascular diseases. Biomarkers of dysl...
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Article
Open AccessValidation of the Children’s International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT
Objectives were to describe the reliability and validity of a new paediatric-specific mucositis scale, the Children’s International Mucositis Evaluation Scale (ChIMES).
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Article
Diverse calving patterns linked to glacier geometry
Iceberg calving—implicated in the retreat of ice shelves—is a complex process constrained by few observations. Numerical simulations suggest that the pattern of iceberg calving is controlled by the geometry of...
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Article
The Vegetation Silica Pool in a Develo** Tidal Freshwater Marsh
Tidal marshes play an important role in the estuarine Si cycle. Dissolved silicon (DSi) is taken up by marsh diatom communities and by tidal marsh vegetation. Delivery of DSi back to the estuary after biogenic...
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Article
Geburtskohortenstudie zu allergischen Erkrankungen bei Kleinkindern in Nordwestdeutschland
Im Rahmen einer Geburtskohortenstudie wurden Ende der 1990er-Jahre in Nordwestdeutschland mehr als 3000 Neugeborene rekrutiert. Einer zur Geburt durchgeführten Basisbefragung folgten nach sechs, zwölf und 24 M...
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Article
The Intestinal Microbial Community of Infants with and Without Necrotising Enterocolitis
Background and aims: Necrotising enterocolitis (NEC), a serious gastrointestinal (GI) disease of prematurity, has a prevalence of 5-10% and mortality rate of 30%. The aetiology is not clearly defined. The GI micr...
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Article
387 Enteral Nutrition and Use of Human Milk Fortifiers in Preterm Infants; An International Survey
Background and aims: Optimal enteral nutrition is of critical importance to preterm infants, but there is limited evidence on benefits and safety of different feeding regimens including use of human milk forti...
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Article
Pneumonia Severity Index: a validation and assessment study for its use as a triage tool in the emergency department
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Article
Update Vorhofflimmer-Chirurgie 2008
In den achtziger Jahren entwarfen Professor Cox und dessen Mitarbeiter die ersten Ansätze der chirurgischen Therapie des Vorhofflimmerns durch eine Fragmentierung beider Vorhöfe mittels einer Schnittund Nahtte...
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Article
Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma
BIC is a primary microRNA (pri-miR-155) that can be processed to mature miR-155. In this study, we show the crucial involvement of protein kinase C (PKC) and nuclear factor-κB (NF-κB) in the regulation of BIC exp...
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Article
Outcome after three years of laronidase enzyme replacement therapy in a patient with Hurler syndrome
Enzyme replacement therapy (ERT) with laronidase, recombinant α-l-iduronidase, for mucopolysaccharidosis type I (MPS I) has been clinically available since April 2003. Pre-approval studies were performed on pati...
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Article
Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little published data on the biological responses to Ad when administered via this rou...
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Article
181 Cooling for Newborns with Hypoxic Ischaemic Encephalopathy
Background: Experimental studies suggest that hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae.
