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Article
Open AccessThe economic burden of pediatric growth hormone deficiency in Italy: a cost of illness study
Growth hormone deficiency (GHD) is a rare condition with a worldwide prevalence of 1 patient in 4000 to 10,000 live births, placing a significant economic burden on healthcare systems. The aim of this study is...
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Article
Open AccessInsights from an Italian Delphi panel: exploring resistance to first-generation somatostatin receptor ligands and guiding second-line medical therapies in acromegaly management
First-line medical therapy for acromegaly management includes first-generation somatostatin receptor ligands (fgSRLs), but resistance limits their use. Despite international guidelines, the choice of second-li...
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Article
Open AccessQuality of life in children and adolescents with growth hormone deficiency and their caregivers: an Italian survey
The aim of this study was to produce evidence on quality of life (QoL) among Italian growth hormone deficiency (GHD) children and adolescents treated with growth hormone (GH) and their parents.
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Article
Open AccessAre there country-specific differences in the use of pegvisomant for acromegaly in clinical practice? An analysis from ACROSTUDY
A comprehensive picture of pegvisomant use for treating acromegaly in routine clinical practice in different countries is lacking. We aimed, therefore, to document country-specific behaviors in real-life pegvi...
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Article
Open AccessFunctional Results after First- and Second-Generation Temporary Implantable Nitinol Device (TIND) for BPH: A Narrative Review of the Literature
In the last decades, new promising technologies for the treatment of BPH-related lower urinary tract symptoms (LUTS) have been widely experienced in clinical practice, with the aim of offering fewer complicati...
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Article
From mini-puberty to pre-puberty: early impairment of the hypothalamus–pituitary–gonadal axis with normal testicular function in children with non-mosaic Klinefelter syndrome
Klinefelter syndrome (KS) is a genetic disorder caused by the presence of an extra X chromosome in males. The aim of this study was to evaluate the hypothalamic–pituitary–gonadal (HPG) axis and the clinical pr...
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Article
Long-term effect of testosterone replacement therapy on bone in hypogonadal men with Klinefelter Syndrome
To assess different aspects of bone damage in untreated adult patients with Klinefelter Syndrome (KS) before and during testosterone replacement therapy (TRT).
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Article
Fluid intelligence, traits of personality and personality disorders in a cohort of adult KS patients with the classic 47, XXY karyotype
Klinefelter’s syndrome (KS) is associated with specific neurobehavioral features and personality traits. The aim of our study was to investigate fluid intelligence, personality traits and personality disorders...
