-
Article
Open AccessTotal osteocalcin levels are independently associated with worse testicular function and a higher degree of hypothalamic–pituitary–gonadal axis activation in Klinefelter syndrome
The role of osteocalcin (OCN) in pubertal development, male hypogonadism, and the effect of testosterone (Te) replacement therapy (TRT) remains unclear. We aimed to investigate the total OCN (tOCN) concentrati...
-
Article
Open AccessUpdate on bioethical, medical and fertility issues in gender incongruence during transition age
Many issues still remain unresolved in the management of pubertal patients with gender incongruence (GI). The aim of this review is to discuss the main aspects of the treatment of these patients to provide a p...
-
Article
Open AccessRisk factors on testicular function in adolescents
Adolescence represents an important window for gonadal development. The aim of this review is to carry out a critical excursus of the most recent literature on endogenous and exogenous risk factors related to ...
-
Article
Open AccessPDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile
Testicular germ cell tumours (TGCTs) is the most common malignancy among young adult males. The etiology is multifactorial and both environmental and genetic factors play an important role in the origin and de...
-
Article
Open AccessAdverse pathophysiological influence of early testosterone therapy on the testes of boys with higher grade sex chromosome aneuploidies (HGAs): a retrospective, cross-sectional study
Higher grade aneuploidies (HGAs) of the male sex chromosomes are a rare genetic group of pathologies caused by nondisjunction meiotic events. The aim of this study was to evaluate the impact of early androgeni...
-
Article
From mini-puberty to pre-puberty: early impairment of the hypothalamus–pituitary–gonadal axis with normal testicular function in children with non-mosaic Klinefelter syndrome
Klinefelter syndrome (KS) is a genetic disorder caused by the presence of an extra X chromosome in males. The aim of this study was to evaluate the hypothalamic–pituitary–gonadal (HPG) axis and the clinical pr...
-
Article
Hormonal and metabolic gender differences in a cohort of myotonic dystrophy type 1 subjects: a retrospective, case–control study
Myotonic dystrophy type 1 (DM1) is a genetic disorder caused by CTG expansion in the DMPK gene. The aim was to investigate the endocrine and metabolic aspects of DM1.
-
Article
Long-term effect of testosterone replacement therapy on bone in hypogonadal men with Klinefelter Syndrome
To assess different aspects of bone damage in untreated adult patients with Klinefelter Syndrome (KS) before and during testosterone replacement therapy (TRT).
-
Article
A multicenter evaluation of immunoassays for follicle-stimulating hormone, luteinizing hormone and testosterone: Concordance, imprecision and reference values
Background: Numerous laboratories in Italy use radioimmunoassay to determine concentrations of sex hormones (FSH, LH, testosterone). A comparison of assay methods is thus an important sta...
-
Article
Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents
Background: As thyroid hormones are essential for normal pubertal growth and sexual development, TSH, free T3 (FT3) and free T4 (FT4) levels undergo progressive modification during childhood and ...
-
Chapter
Actin Proteolysis in San Daniele Dry-Cured Ham
The aim of this work was to define the actin degradation pattern during the production of dry-cured San Daniele ham, as a factor that could influence its ripening and sensory characteristics. Biceps femoris muscl...
-
Article
Growth hormone deficiency in the transition period: Body composition and gonad function
Recombinant GH therapy is normally administered to GH-deficient children in order to achieve a satisfactory height — the main target during childhood and adolescence. However, the role of GH does not end once ...
-
Article
Protein breakdown and volatile profile of low-acid sausages from crossbreed pigs
