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within S. A. Karim Remove this filter Medicine & Public Health Remove this filter English Remove this filter Human Genetics Remove this filter Medicine/Public Health, general Remove this filter

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  1. Article

    Open Access

    Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

    Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival and tumour growth. Pancreatic cancer is one of the...

    A J Rice, E Cortes, D Lachowski, B C H Cheung, S A Karim, J P Morton… in Oncogenesis (2017)

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  2. Article

    Open Access

    Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

    Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as an RCP-binding protein and showed that mutant p53 p...

    P A J Muller, A G Trinidad, P Timpson, J P Morton, S Zanivan… in Oncogene (2013)

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