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  1. No Access

    Article

    The pathogenesis of mucositis: updated perspectives and emerging targets

    Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature re...

    J. Bowen, N. Al-Dasooqi, P. Bossi, H. Wardill, Y. Van Sebille… in Supportive Care in Cancer (2019)

  2. No Access

    Article

    A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation

    Interleukin-11 (IL-11) decreases cytokine release and increases survival in murine BMT models. In these systems, it reduces gut permeability, partially polarizes T cells to a Th2 phenotype, down-regulates IL-1...

    JH Antin, SJ Lee, D Neuberg, E Alyea, RJ Soiffer, S Sonis… in Bone Marrow Transplantation (2002)

  3. No Access

    Article

    The biological basis for the attenuation of mucositis: the example of interleukin-11

    Oral mucositis is common, painful, dose-limiting toxicity of drug and radiation therapy for cancer. In granulocytopenic patients, the ulcerations which accompany mucositis are frequent portals of entry for ind...

    S Sonis, L Edwards, C Lucey in Leukemia (1999)

  4. No Access

    Article

    Assessment of Drug Sensitivity of Human Leukaemic Myeloblasts

    The compound 125IUdR can be incorporated in a stable form into the DNA of cells. The isotope is released if labelled cells or their progeny die. Consequently the rate of 125I excretion from mice can be used to fo...

    R P FalcãO, S Sonis, I C M MacLennan, D Chassoux, A J S Davies… in British Journal of Cancer (1977)