73 Result(s)

Article

Identification of vascular endothelial cells in murine omentum using the lectin,Dolichos biflorus agglutinin: Possible applications in the study of angiogenesis

The purpose of this study was to determine whether the plant lectin,Dolichos biflorus agglutinin (DBA), can be used to recognize capillary endothelial cells and their processes during angiogenesis. By means of a ...

Rhodri J. LL. Williams, David Robertson, A. J. S. Davies in The Histochemical Journal (1989)

Chapter

An experimental study of xenografted human gliomas

Chemotherapy of human astrocytomas growing as subcutaneous xenografts in mice revealed that the Grade III tumours were relatively insensitive but that agents such as procarbazine and BCNU were capable of procu...

H. J. G. Bloom, N. J. Bradley, A. J. S. Davies, S. G. Richardson in Biology of Brain Tumour (1986)

Chapter

Exploiting Lymphocyte Traffic to Deliver Radioactivity or Ricin to Lymphatic Tissues

After injection into the bloodstream lymphocytes localize in the traffic areas of the spleen and lymph nodes where they reach a concentration approximately 500 times greater than the concentration averaged ove...

W. L. Ford, A. J. S. Davies, M. Birch… in Microenvironments in the Lymphoid System (1985)

Chapter

Targeting Toxins by Conjugation to Antibodies: The Effect of the Linkage Group on Biological Activity

Interest is growing in the potential use of conjugates of antibodies and toxins or their A chains as therapeutic agents. So far, convincing evidence has been presented on the in vitro efficacy and selectivity of ...

D. C. Edwards, W. C. J. Ross, A. J. Cumber… in Investigation of Membrane-Located Receptors (1984)

Article

Cancer Immunology & Parasite Immunology

A J S Davies in British Journal of Cancer (1982)

Article

The effect of abrin, anti-lymphocyte globulin and their conjugates on the immune response of mice to sheep red blood cells

A chemical conjugate of anti-mouse lymphocyte globulin and abrin, is about twice as effective as a similar conjugate made with normal immunoglobulin and abrin, in suppressing the ability of the mouse to respon...

D. C. Edwards, A. Smith, W. C. J. Ross, A. J. Cumber, P. E. Thorpe… in Experientia (1981)

Article

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

Peanut (Arachis hypogaea) lectin (PNL) has been shown to agglutinate the 90% of cells from murine thymus which are supposed to be immature cortical thymocytes¹. Further studies on the numbers of thymocytes bindin...

M. L. Rose, M. S. C. Birbeck, V. J. Wallis, J. A. Forrester, A. J. S. Davies in Nature (1980)

Chapter

Immunodeficient animals

The idea of implantation of human tumours into experimental animal hosts is not new. It is, in some senses, an extension of the many ways in which transplantation of animal tissues and organs to the human spec...

A. J. S. Davies in Immunodeficient Animals for Cancer Research (1980)

Article

Serum amyloid P-component is an acute-phase reactant in the mouse

THE acute-phase reaction in mammals is characterised by an increase in the concentration of certain plasma proteins which starts within hours or days of most forms of acute tissue damage or inflammation, and p...

M. B. PEPYS, MARILYN BALTZ, K. GOMER, A. J. S. DAVIES, M. DOENHOFF in Nature (1979)

Article

The influence of thymus on the development of MHC restrictions exhibited by T-helper cells

IMMUNE functions depend largely on the activities of peripheral lymphocytes which have been ‘processed’ in the thymus (T cells). The best characterised activities of these cells, such as in vitro cytotoxicity and...

H. WALDMANN, HEATHER POPE, CLAIRE BETTLES, A. J. S. DAVIES in Nature (1979)

Article

Thoughts on ageing

Endurance of Life: Implications of Genetics for Human Life.

A. J. S. Davies in Nature (1978)

Article

Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin

THERE is a pressing need in medicine for cytotoxic agents with tissue specificity. It may be possible to produce such agents by conjugating cytotoxic materials, themselves lacking inherent specificity, to anti...

P. E. THORPE, W. C. J. Ross, A. J. CUMBER, C. A. HINSON, D. C. EDWARDS… in Nature (1978)

Chapter

Categorization of Non-Hodgkin’s Hematosarcomas (Lymphomas) According to T- and B-Cell Markers: Its Value for Diagnosis and Prognosis

Non-Hodgkin’s hematosarcomas (NHHS) or non-Hodgkin’s “lymphomas” are the objects of so many different morphologic microscopic classifications [12,17, 23, 24, 26, 27, 31, 33, 34, 36, 38, 39] that it is almost i...

D. Belpomme, B. Caillou, N. Lelarge, I. Botto, E. Pujade Lauraine… in Lymphoid Neoplasias I (1978)

Article

Assessment of Drug Sensitivity of Human Leukaemic Myeloblasts

The compound ¹²⁵IUdR can be incorporated in a stable form into the DNA of cells. The isotope is released if labelled cells or their progeny die. Consequently the rate of ¹²⁵I excretion from mice can be used to fo...

R P FalcãO, S Sonis, I C M MacLennan, D Chassoux, A J S Davies… in British Journal of Cancer (1977)

Chapter and Conference Paper

Studies on the Mitotic Responsiveness of “T” Cells After Stimulation with Contact Sensitizing Agents

Oxazolone, in common with other contact sensitizing agents such as picryl chloride, induces in the lymph nodes draining its site of application a complex series of reactive changes (9, 15). These changes inclu...

A. J. S. Davies, V. J. Wallis, E. Leuchars… in Experimental Models of Chronic Inflammator… (1977)