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  1. No Access

    Article

    Prognostic impact of FOXF1 polymorphisms in gastric cancer patients

    A recent genome-wide association study identified seven single-nucleotide polymorphisms (SNPs) in region 16q24, near the Forkhead box-F1 (FOXF1) gene, which confer susceptibility to esophageal adenocarcinoma. We ...

    S Matsusaka, A H Wu, S Cao, D L Hanna, K Chin, D Yang… in The Pharmacogenomics Journal (2018)

  2. No Access

    Article

    A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials

    The Hippo pathway is involved in colorectal cancer (CRC) development and progression. The Hippo regulator Rassf1a is also involved in the Ras signaling cascade. In this work, we tested single nucleotide polymo...

    A Sebio, S Stintzing, V Heinemann, Y Sunakawa, W Zhang… in The Pharmacogenomics Journal (2018)

  3. No Access

    Article

    Clinical relevance of EMT and stem-like gene expression in circulating tumor cells of metastatic colorectal cancer patients

    Using approved methods, circulating tumor cells (CTCs) are only isolated from blood in 30%–50% of metastatic colorectal cancer (mCRC) patients. We previously validated a technique to isolate circulating tumor ...

    Y Ning, W Zhang, D L Hanna, D Yang, S Okazaki, M D Berger… in The Pharmacogenomics Journal (2018)

  4. No Access

    Article

    Genetic variations in immunomodulatory pathways to predict survival in patients with locoregional gastric cancer

    Immunomodulator-targeting therapies are under development in gastric cancer (GC). However, the role of genes modulating anti-tumor immunity in GC remains poorly understood. We investigated the association of v...

    Y Sunakawa, S Cao, N B Volz, M D Berger, D Yang, A Parekh… in The Pharmacogenomics Journal (2017)

  5. No Access

    Article

    CXCR4 polymorphism predicts progression-free survival in metastatic colorectal cancer patients treated with first-line bevacizumab-based chemotherapy

    We analyzed associations between CXCR4/CXCL12 single-nucleotide polymorphisms and outcomes in metastatic colorectal cancer (mCRC) patients who underwent first-line bevacizumab-based chemotherapy. A total of 874 p...

    S Matsusaka, S Cao, D L Hanna, Y Sunakawa, M Ueno… in The Pharmacogenomics Journal (2017)

  6. No Access

    Article

    Genetic variants associated with colorectal brain metastases susceptibility and survival

    Colorectal brain metastases (BM) are rare (1–2%) and a late-stage disease manifestation. Molecular mechanisms for BM development are not well understood. We tested whether variants within genes involved in ove...

    S Stremitzer, A S Berghoff, N B Volz, W Zhang, D Yang… in The Pharmacogenomics Journal (2017)

  7. No Access

    Article

    Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer

    Estrogen has been shown not only to reduce the incidence of colorectal cancer but also gastric cancer (GC). Polymorphisms in estrogen receptor β gene, ESR2, correlate with colorectal cancer survival. To better un...

    Y Sunakawa, S Cao, M D Berger, S Matsusaka, D Yang, W Zhang… in The Pharmacogenomics Journal (2017)