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Article
Prediction of early (30-day) and late (30–90-day) mortality after radical cystectomy in a comprehensive cancer centre over two decades
Radical cystectomy (RC) is associated with substantial postoperative mortality. In this study, we analyzed early (30-day; 30 M) and late (30–90-day; 30–90 M) mortality after RC in a Dutch tertiary referral cen...
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Article
Open AccessCryoablation and immunotherapy: an overview of evidence on its synergy
Cancer cells can escape the immune system by different mechanisms. The evasion of cancer cells from immune surveillance is prevented by immune checkpoint inhibitors, allowing the patient’s own immune system to...
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Article
Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy
Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the t...
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Article
Open Access(Cost-)effectiveness of an internet-based physical activity support program (with and without physiotherapy counselling) on physical activity levels of breast and prostate cancer survivors: design of the PABLO trial
Higher levels of physical activity (PA) after treatment are associated with beneficial effects on physical and psychosocial functioning of cancer survivors. However, survivors often do not meet the recommended...
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Article
Open AccessThe best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes
Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how flu...
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Article
Open AccessShort-term outcome after cystectomy: comparison of early oral feeding in an enhanced recovery protocol and feeding using Bengmark nasojejunal tube
Cystectomy for bladder cancer is associated with a high risk of postoperative complications. Standardized perioperative protocols, such as enhanced recovery after surgery (ERAS) protocols, aim to improve posto...
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Article
FDG-PET/CT for response evaluation of invasive bladder cancer following neoadjuvant chemotherapy
We investigated the accuracy of FDG-PET/CT response identification following neoadjuvant or induction chemotherapy (NAIC) for invasive bladder cancer (BC) as to better select patients for radical cystectomy (RC).
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Article
Sentinel node biopsy and lymphatic map** in penile and prostate cancer
Nodal metastases are linked to poor outcome in men with penile or prostate cancer. Early detection and resection are important for staging and for the prognosis. However, lymphadenectomy is associated with mor...
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Article
Vimentin over-expression and carbonic anhydrase IX under-expression are independent predictors of recurrence, specific and overall survival in non-metastatic clear-cell renal carcinoma: a validation study
Clinical outcomes prognostic markers are awaited in clear-cell renal carcinoma (ccRCC) to improve patient-tailored management and to assess six different markers’ influence on clinical outcomes from ccRCC spec...
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Article
Open AccessBeyond penile cancer, is there a role for sentinel node biopsy in urological malignancies?
This review aims to discuss the current state-of-the-art of sentinel node (SN) map** in urological malignancies. The principles and methodological aspects of lymphatic map** and SN biopsy in urological mal...
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Article
Potentially curable recurrent disease after surgically managed non-metastatic renal cell carcinoma in low-, intermediate- and high-risk patients
Guidelines recommend risk-adapted follow-up (FU) strategies after (partial) nephrectomy in non-metastatic renal cell carcinoma (RCC). Since current systemic therapy does not cure metastatic RCC, only timely de...
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24 Tumor-infiltrerende lymfocyten en relatie met uitkomst en HPV-status bij peniscarcinoom
Van veel tumorsoorten bestaat bewijs dat tumorprogressie wordt beïnvloed door het immuunsysteem van de gastheer. Tumorinfiltrerende lymfocyten (TILs), zoals regulatoire T-lymfocyten (Tregs) en cytotoxische T-l...
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Article
22 Neoadjuvante dose-dense MVAC voor spierinvasief blaascarcinoom
Neoadjuvante cisplatinehoudende chemotherapie voor spierinvasief blaascarcinoom resulteert bij 30- 40% van de patiënten tot complete pathologische respons (CPR) en een betere overleving dan cystectomie alleen.
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Article
27 Tumorgeassocieerde macrofagen (TAMs) en relatie met uitkomst en HPV-status bij peniscarcinoom
Voor veel tumorsoorten bestaat er bewijs dat tumorprogressie wordt beïnvloed door het immuunsysteem van de gastheer. Macrofagen in tumoren (TAMs) zijn belangrijke regulatoren van onder andere T-celresponssuppr...
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Article
23 De voorspellende waarde van pretherapie tumorvolume bij patiënten met intermediate risk MSKCC-gemetastaseerd niercelcarcinoom
Patiënten met gemetastaseerd niercelcarcinoom reageren verschillend op targeted therapie, zelfs als de MSKCC- en Heng-scores vergelijkbaar zijn. Deze studie is opgezet om te analyseren of het tumorvolume een voor...
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Article
42 Prevalentie en prognostische waarde van het humaan papillomavirus (HPV) in peniscarcinoom
Een van de risicofactoren voor peniscarcinoom (PC) is een infectie met hoogrisicotypes van het humaan papillomavirus (hrHPV).
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Article
3 ‘Human Leukocyte Antigen’ klasse 1-expressie in peniscarcinoom en relatie met klinische parameters
Tumorcellen kunnen eigenschappen verwerven waarmee ze ontsnappen aan herkenning en vervolgens eliminatie door het immuunsysteem.
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Article
26 Resultaten van 20 jaar prostaatsparende cystectomie voor blaascarcinoom
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Article
Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival
To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates.
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Article
8 De waarde van echogeleide cytologische punctie in de follow-up van de liesklieren bij peniscarcinoom