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Open AccessTumor-infiltrating lymphocytes in HER2-positive breast cancer treated with neoadjuvant chemotherapy and dual HER2-blockade
Tumor-infiltrating lymphocytes (TILs) have been associated with outcomes in HER2-positive breast cancer patients treated with neoadjuvant chemotherapy and trastuzumab. However, it remains unclear if TILs could...
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Article
Open AccessTumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma
Immune checkpoint inhibition (ICI) has improved patients’ outcomes in advanced melanoma, often resulting in durable response. However, not all patients have durable responses and the patients with dissociated ...
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Article
Open AccessImproved calorimetric particle identification in NA62 using machine learning techniques
Measurement of the ultra-rare K + → ...
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Open AccessA study of the K+ → π0e+νγ decay
A sample of 1.3 × 105 K+ → π0e+νγ candidates with less than 1% background was collected by the NA62 experiment at the CERN SPS in 2017–2018. Branching fraction measurements are obtained at percent relative precis...
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Open AccessSearch for dark photon decays to μ+μ− at NA62
The NA62 experiment at CERN, designed to study the ultra-rare decay K+ → π+ ν ν ...
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Open AccessBluePrint molecular subtypes predict response to neoadjuvant pertuzumab in HER2-positive breast cancer
The introduction of pertuzumab has greatly improved pathological complete response (pCR) rates in HER2-positive breast cancer, yet effects on long-term survival have been limited and it is uncertain which pati...
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Open AccessIncidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria
Almost two million stillbirths occur annually, most occurring in low- and middle-income countries. Nigeria is reported to have one of the highest stillbirth rates on the African continent. The aim was to ident...
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Open AccessA qualitative focus group study concerning perceptions and experiences of Nigerian mothers on stillbirths
To explore the experiences and perceptions of stillbirth among mothers from a tertiary medical centre in Kano, Northern Nigeria.
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Correction: Management of nystagmus in children: a review of the literature and current practice in UK specialist services
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Management of nystagmus in children: a review of the literature and current practice in UK specialist services
Nystagmus is an eye movement disorder characterised by abnormal, involuntary rhythmic oscillations of one or both eyes, initiated by a slow phase. It is not uncommon in the UK and regularly seen in paediatric ...
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Open AccessPractical applications of studies on the TSH receptor and TSH receptor autoantibodies
Studies on the TSH receptor (TSHR) have numerous practical applications in vitro and in vivo. For example human monoclonal autoantibodies (MAbs) to the TSHR are useful reagents for in vitro diagnostics. Measur...
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Open AccessTissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study
In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition cou...
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Open AccessImplementation of the Family Nurse Partnership programme in England: experiences of key health professionals explored through trial parallel process evaluation
The Family Nurse Partnership (FNP) programme was introduced to support young first-time mothers. A randomised trial found FNP added little short-term benefit compared to usual care. The study included a compre...
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SPECT/CT technology
The continuous development of SPECT over the past 50 years has led to remarkably improved image quality and increased diagnostic confidence. The most influential developments include the realization of hybrid ...
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3 ‘Human Leukocyte Antigen’ klasse 1-expressie in peniscarcinoom en relatie met klinische parameters
Tumorcellen kunnen eigenschappen verwerven waarmee ze ontsnappen aan herkenning en vervolgens eliminatie door het immuunsysteem.
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Enhanced sensitivity of the LIGO gravitational wave detector by using squeezed states of light
Nearly a century after Einstein first predicted the existence of gravitational waves, a global network of Earth-based gravitational wave observatories1,2,3,4 is seeking to directly detect this faint radiation usi...
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Open AccessThe role of p21-activated kinase in the initiation of atherosclerosis
p21-activated kinase (PAK) has been implicated in the inflammatory activation of endothelial cells by disturbed fluid shear stress, which is the initiating stimulus in atherosclerosis. The study addresses whet...
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Tissue oxygen saturation during anaesthesia, cardiopulmonary bypass and intensive care stay for cardiac surgery
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Autologous bone marrow transplantation for children with AML in first remission
In Children's cancer group (CCG) 2891, newly diagnosed patients with AML were randomized between standard and intensive timing induction therapies. Patients in first remission who lacked an HLA matched family ...
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Unravelling the genome: a review of molecular genetic research in schizophrenia
Schizophrenia is a common and complex mental illness that affects approximately 1% of the population worldwide. Despite intensive research over the years, the aetiology and pathogenesis of schizophrenia is poo...