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  1. No Access

    Article

    Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences

    The influence of oxaliplatin (OXA) on 5-fluorouracil (5-FU) plasma clearance was investigated. Patients and methods: A group of 29 patients with advanced colorectal cancer refractory to prior weekly 8-h 5-FU inf...

    M. Boisdron-Celle, M. Craipeau, S. Brienza… in Cancer Chemotherapy and Pharmacology (2002)

  2. Article

    Open Access

    Factors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) ± folinic acid in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer patients

    A statistical analysis was performed on the patient data collected from two compassionate-use programmes using oxaliplatin (Eloxatin®) + 5-fluorouracil (5-FU) ± folinic acid (FA), to identify predictive factor...

    M A Bensmaïne, M Marty, A de Gramont, S Brienza, F Lévi… in British Journal of Cancer (2001)

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  3. No Access

    Chapter

    Implications of Chronobiology for 5-Fluorouracil (5-Fu) Efficacy

    The drug 5-fluorouracil (5-FU) has remained the main active drug against gastrointestinal malignancies. Both its tolerability and/or its efficacy have been increased through combination with folinic acid (FA) ...

    F. Lévi, S. Brienza, G. Metzer… in Novel Approaches to Selective Treatments o… (1993)

  4. No Access

    Chapter

    Oxalatoplatinum (I-OHP): Experimental and Clinical Studies

    1,2 diamino cychlohexane (trans-I) oxalatoplatinum II was isolated by Kidani among isomeric mixture of DACH derivatives of Platinum as yielding the highest survival increment on L1210 leukemia.

    J. L. Misset, Y. Kidani, J. Gastiaburu… in Platinum and Other Metal Coordination Comp… (1991)

  5. No Access

    Chapter and Conference Paper

    Intensive and prolonged first line chemotherapy in breast cancer

    One hundred and eleven patients presenting a breast cancer were treated with intensive and prolonged chemotherapy from 1980 to 1990. Medium age is 50, 2 patients have less than 20 and 5 more than 70. All fulfi...

    F. Burki, J-L. Misset, M. Musset… in Proceedings of the 3rd International Congr… (1991)