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Article
Open AccessCircadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer
Urinary levels of modified nucleosides reflect nucleic acids turnover and can serve as non-invasive biomarkers for monitoring tumour circadian dynamics, and treatment responses in patients with metastatic colo...
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Chapter
Cancer Chronotherapeutics: Experimental, Theoretical, and Clinical Aspects
The circadian timing system controls cell cycle, apoptosis, drug bioactivation, and transport and detoxification mechanisms in healthy tissues. As a consequence, the tolerability of cancer chemotherapy varies ...
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Article
Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis
Cetuximab was approved using a weekly schedule, alone or in combination with chemotherapy (CT). However, many CT regimens in metastatic colorectal cancer (CRC) are delivered every 2 weeks (q2wks). Preliminary ...
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Article
Open AccessPreclinical relevance of dosing time for the therapeutic index of gemcitabine–cisplatin
The relevance of gemcitabine timing for chronotherapeutic optimisation was investigated. Healthy mice received multiple doses of gemcitabine (120, 160 or 200 mg kg−1 injection (inj)−1) at one of six circadian tim...
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Article
Open AccessCircadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma
The relevance of circadian rhythms in irinotecan and oxaliplatin tolerability was investigated with regard to antitumour activity. Mice bearing Glasgow osteosarcoma (GOS) received single agent irinotecan (50 o...
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Article
Open AccessFactors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) ± folinic acid in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer patients
A statistical analysis was performed on the patient data collected from two compassionate-use programmes using oxaliplatin (Eloxatin®) + 5-fluorouracil (5-FU) ± folinic acid (FA), to identify predictive factor...
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Chapter
Chronopharmacology of Anticancer Agents
Several strategies are aimed at increasing the selectivity of anticancer agents against cancer cells. Some are based on tumor cell biology: new drug development, resistance revertants, etc. Others are targeted...
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Article
Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: relationships with tumour marker antigens
Few data are available on the circadian rhythmicity in cancer patients. Since monitoring the disease usually implies the follow-up of blood concentrations of a number of biological variables, it would be of va...
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Chapter
Implications of Chronobiology for 5-Fluorouracil (5-Fu) Efficacy
The drug 5-fluorouracil (5-FU) has remained the main active drug against gastrointestinal malignancies. Both its tolerability and/or its efficacy have been increased through combination with folinic acid (FA) ...
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Chapter
Immune System in Relation to Cancer
Through its continuous interactions with the environment, the immune system constitutes one of the major sources of external information of the organism.
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Chapter
Oxalatoplatinum (I-OHP): Experimental and Clinical Studies
1,2 diamino cychlohexane (trans-I) oxalatoplatinum II was isolated by Kidani among isomeric mixture of DACH derivatives of Platinum as yielding the highest survival increment on L1210 leukemia.
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Article
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Chapter and Conference Paper
Clinical Chronopharmacology and Chronotherapy of Asthma
As a result of endogenous biological rhythms both desired and undesired effects of a therapeutic agent vary as a function of the time at which it is given in the 24 h scale among other periods. Emphasis will b...
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Article
Distribution de la morphologie des tumeurs incidentes dans le canton de Vaud
After a short presentation of the methodological aspects of cancer registration and morphological coding, the results concerning cancer of the upper digestive tract, lung, testis and ovary were discussed. Some...
