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Article
Alterations in the estrogen receptor profile of cardiovascular tissues during aging
Estrogen exerts protective effects on the cardiovascular system via three known estrogen receptors: alpha (ERα), beta (ERß), and the G protein-coupled estrogen receptor (GPER). Our laboratory has previously sh...
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Article
Measuring Respiration in Isolated Murine Brain Mitochondria: Implications for Mechanistic Stroke Studies
Measuring mitochondrial respiration in brain tissue is very critical in understanding the physiology and pathology of the central nervous system. Particularly, measurement of respiration in isolated mitochondr...
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Article
Open AccessEstrogen receptor profiles across tissues from male and female Rattus norvegicus
Estrogen is formed by the enzyme aromatase (CYP19A1) and signals via three identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor (GPER). Understanding the relative contributi...
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Article
Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure
Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of...
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Article
Open AccessHDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference
Sexual difference has been shown in the pathogenesis of chronic kidney disease induced by hypertension. Females are protected from hypertension and related end-organ damage. Augmentation of renal proximal tubu...
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Article
Regulation of a novel angiotensin II precursor, proangiotensin-12, in the tissues by blockade of the renin–angiotensin system
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Article
Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury
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Article
Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways
Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pa...
