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Open AccessIntrarenal renin–angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis
The current study tested the hypothesis that urinary angiotensinogen (UAGT) and urinary monocyte chemoattractant protein-1 (UMCP-1) levels provide a specific index of intrarenal renin–angiotensin system (RAS) ...
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Article
Assessment of catabolic state in infants with the use of urinary titin N-fragment
Urinary titin N-fragment levels have been used to assess the catabolic state, and we used this biomarker to evaluate the catabolic state of infants.
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Article
Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)
Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to c...
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Article
Open AccessMolecular diagnosis of an infant with TSC2/PKD1 contiguous gene syndrome
A 1-month-old Japanese infant with cardiac rhabdomyoma was diagnosed with TSC2/PKD1 contiguous gene syndrome by targeted panel sequencing with subsequent quantitative polymerase chain reaction that revealed gross...
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Article
Reduction in urinary angiotensinogen levels and improvement of proteinuria by renin–angiotensin system blockade in pediatric chronic kidney disease patients with very low birth weight
Children with low birth weight (LBW) have an increased risk of develo** chronic kidney disease (CKD), and no effective strategies have been established to prevent the progression of CKD in these patients. Ur...
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Article
Successful treatment with voriconazole combined with amphotericin B-liposome for fluconazole-resistant pulmonary cryptococcosis after renal transplantation
Cryptococcosis is an invasive fungal infection that is common among organ transplant recipients, and it is challenging to treat among these patients because of their immunocompromised status. Fluconazole (FLCZ...
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Article
Enhanced angiotensinogen expression in neonates during kidney development
We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with ...
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Article
Role of the intrarenal renin–angiotensin system in the progression of renal disease
The intrarenal renin–angiotensin system (RAS) has many well-documented pathophysiologic functions in both blood pressure regulation and renal disease development. Angiotensin II (Ang II) is the major bioactive...
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Article
Intrarenal renin-angiotensin system activation in end-stage renal disease
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Article
(Pro)renin and (pro)renin receptor expression during kidney development in neonates
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the develo** kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal devel...
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Article
Open AccessEvidence-based clinical practice guidelines for IgA nephropathy 2014
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Article
Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients
Recently, we demonstrated that urinary angiotensinogen (AGT) levels are increased and reflect intrarenal renin–angiotensin system (RAS) status in pediatric patients with chronic glomerulonephritis. Therefore, ...
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Article
Urinary angiotensinogen level is increased in preterm neonates
All components of the renin–angiotensin system (RAS) are abundantly synthesized in the develo** kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human n...
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Article
A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection
Infantile systemic lupus erythematosus (iSLE) is extremely rare. Patients with iSLE usually become severely unwell and have poor prognosis. Epstein–Barr virus (EBV) infection has been implicated in the develop...
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Article
Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease
Activated intrarenal renin–angiotensin system plays a cardinal role in the pathogenesis of hypertension and chronic kidney disease. Angiotensinogen is the only known substrate for renin, which is the rate-limi...
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Article
A case of a 6-year-old girl with anti-neutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis
A 6-year-old girl was admitted to our hospital with proteinuria, hematuria, skin rash and joint pain of the lower limbs. Due to rapid progression of renal insufficiency, hemodialysis and peritoneal dialysis we...
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Article
Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways
Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pa...
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Article
Open AccessGlomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy
Enhanced intrarenal renin-angiotensin system (RAS) is implicated in the development and progression of renal injury. To investigate whether angiotensinogen (AGT) expression is involved in glomerular RAS activi...
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Article
Transforming growth factor-β in renal disease with glycogen storage disease I
We report a 14-year-old patient with Japanese glycogen storage disease I (GSD-I) who was found to have proteinuria. Renal biopsy revealed massive tubular atrophy and interstitial fibrosis with mononuclear cell...
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Article
Sisters with α-mannosidosis and systemic lupus erythematosus
Alpha-mannosidosis is an autosomal recessive disorder caused by deficiency of lysosomal α-mannosidase (LAMAN). Here, we report two sisters with α-mannosidosis who developed systemic lupus erythematosus (SLE). ...
