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Comprehensive characterization of protein–protein interactions perturbed by disease mutations

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  1. Article

    Open Access

    KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene

    Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therape...

    Melyssa S. Roberts, Lindsey J. Anstine, Viviane S. Finke… in Breast Cancer Research (2020)

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  2. Article

    Open Access

    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer

    Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...

    Darcie D. Seachrist, Steven T. Sizemore, Emhonta Johnson… in Breast Cancer Research (2017)

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  3. Article

    Open Access

    Intrinsic bias in breast cancer gene expression data sets

    While global breast cancer gene expression data sets have considerable commonality in terms of their data content, the populations that they represent and the data collection methods utilized can be quite disp...

    Jonathan D Mosley, Ruth A Keri in BMC Cancer (2009)

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