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Chapter
Ultraschalldiagnostik
Ultraschalldiagnostik ist heute in nahezu allen medizinischen Fachbereichen eine wichtige bildgebende Methode. Im Vordergrund stehen hierbei die schnelle, einfache und insbesondere wirtschaftliche Anwendbarkei...
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Living Reference Work Entry In depth
Ultraschalldiagnostik – Geräteaufbau, Doppler und Methoden
Ultraschalldiagnostik ist heute in nahezu allen medizinischen Fachbereichen eine wichtige bildgebende Methode. Im Vordergrund stehen hierbei die schnelle, einfache und insbesondere wirtschaftliche Anwendbarkei...
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Chapter
Ultrasound Diagnostics
Today, ultrasound diagnostics is an important imaging method in virtually all medical fields. The fact that it is quick, simple and in particular cost-efficient plays a major role in this. Further advantages a...
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Article
Open AccessInter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression
Cadherin cell adhesion molecules play an essential role in creating tight intercellular association and their loss has been correlated with poor prognosis in human cancer. Mutational activation of protein kina...
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Article
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
Bag1 is a cochaperone for the heat-shock protein Hsp70 that interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins. Here we use targeted gene disruption in mice to show that Bag1...
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Article
Open AccessBAG-1 haplo-insufficiency impairs lung tumorigenesis
BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signali...
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Article
Open AccessUse of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure
Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of ...
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Article
The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons
The avian ITA is homologous to the baculoviral and mammalian inhibitor of apoptosis (IAP) proteins, which can prevent apoptosis by inhibition of specific caspases. We investigated the role of ITA in embryonic ...
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Article
Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons
The neurotrophic factors ciliary neurotrophic factor and brainderived neurotrophic factor can prevent motor neuron cell death during development1,2 and after nerve lesion in neonatal rodents3,4. However, local an...
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Article
Neurotrophin-6 is a new member of the nerve growth factor family
DURING vertebrate development, many neurons depend for survival and differentiation on their target cells1–3. The best documented mediator of such a retrograde trophic action is the neurotrophin nerve growth fact...
