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Article
Open AccessUrinary metabolomics signature of animal and plant protein intake and its association with 24-h blood pressure: the African-PREDICT study
The contrasting relationships of plant and animal protein intake with blood pressure (BP) may be partially attributed to the differential non-protein (e.g., saturated fat and fibre) and amino acid (AA) composi...
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Article
Open AccessHypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities
Recent global and regional reports consistently confirm the high and increasing prevalence of hypertension in sub-Saharan Africa (SSA), with poor detection, treatment, and control rates. This narrative review ...
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Article
Open AccessTwenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study
Hypertension and obesity are known pro-inflammatory conditions, and limited studies explored various blood pressure modalities and inflammatory markers in young adults with overweight or obesity (OW/OB). We as...
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Article
Open AccessEarly vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies
Some individuals are susceptible to accelerated biological ageing, resulting in premature alterations in arterial structure and function. Identifying early-onset vascular ageing characterised by arterial stiffe.....
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Article
Open AccessMarkers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study
Increased exposure to risk factors in the young and healthy contributes to arterial changes, which may be accompanied by an altered metabolism.
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Article
A urinary peptidomics approach for early stages of cardiovascular disease risk: The African-PREDICT study
Cardiovascular disease (CVD) affects individuals across the lifespan, with multiple cardiovascular (CV) risk factors increasingly present in young populations. The underlying mechanisms in early cardiovascular...
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Article
Urinary metabolomics, dietary salt intake and blood pressure: the African-PREDICT study
In Black populations excessive salt intake may exacerbate the genetic predisposition to hypertension and promote the early onset of cardiovascular disease. Ethnic differences in the interaction between sodium ...
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Article
Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies
Individuals with masked hypertension (MHT) have a greater risk of adverse cardiovascular outcomes than normotensive (NT) individuals. Exploring metabolomic differences between NT and MHT individuals may help p...
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Article
Correction to: Growth differentiating factor-15 and adiposity in young adults: The African-PREDICT study
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Article
Open AccessSpecific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Hypusination is a unique two-step enzymatic post-translational modification of the Nε-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A). We developed a specific and sensitive gas chromatogra...
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Article
Open AccessDevelopment, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine
A gas chromatography-mass spectrometry (GC–MS) method was developed and validated in relevant concentration ranges for the simultaneous measurement of l-lysine (Lys, L) and its Nε- and Nα-methylated (M), Nε- and
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Article
Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study
Lower nitric oxide (NO) bioavailabilty associates with hypertension in patients and elderly populations. With hypertension known to develop earlier in black populations, we compared both plasma and urinary NO-...
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Article
Growth differentiating factor-15 and adiposity in young adults: The African-PREDICT study
Circulating growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine that increases in older individuals with established cardiovascular disease (CVD) and obesity. To address potential targets...
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Article
Racial differences of early vascular aging in children and adolescents
The prevalence of non-communicable disease (NCDs) is rising globally, with a large burden recorded in sub-Saharan countries and populations of black race/ethnicity. Accelerated vascular deterioration, otherwis...
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Article
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability. We compared plasma and urinary NO-related markers and plasma creatine kinase (CK) levels be...
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Article
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
Nitric oxide plays an important role in maintaining endothelial function, while increased oxidative stress may lead to nitric oxide inactivation and cardiovascular disease. If nitric oxide biosynthesis/bioavai...
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Article
Correction: Morning blood pressure surge in young black and white adults: The African-PREDICT Study
In the article “Morning blood pressure surge in young black and white adults: The African-PREDICT Study” by Gontse Gratitude Mokwatsi, Aletta Elisabeth Schutte, Catharina Martha Cornelia Mels and Ruan Kruger w...
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Article
Morning blood pressure surge in young black and white adults: The African-PREDICT Study
An exaggerated morning blood pressure surge (MBPS) has independent predictive value for cardiovascular mortality and is suggested to be prevalent in elderly hypertensive patients: men and white populations. To...
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Article
Correction to: Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study
In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected.
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Article
Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study
There is global consensus on the benefits of reducing excessive salt intake. Indeed, lower salt intake associates with reduced arterial stiffness, a well-established predictor of cardiovascular risk, in older ...
