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Article
Open AccessAssociation of osteoporotic fractures of femoral neck and femoral neck geometric parameters in native Chinese women
Although it is generally believed that the femoral neck fracture is related to the femoral neck geometric parameters (FNGPs), the association between the risk of osteoporotic fracture of the femoral neck and F...
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Article
A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk
The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk. At 31 study centers ...
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Article
Open AccessRelationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China
Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched. Little is known about the relationship between BMD and fragility fracture...
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Article
Open AccessAge-related bone turnover markers and osteoporotic risk in native Chinese women
The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study ...
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Article
The Influence of Center of Rotation on the Assessment of Trabecular Bone Densitometric and Structural Properties
The center of rotation is a physical location in the microCT scanner, defined by the axis of rotation of the sample stage. This physical location is always well defined during calibration of the instrument and...
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Article
Establishment of BMD reference databases for the diagnosis and evaluation of osteoporosis in central southern Chinese men
Osteoporosis in men is an increasingly important public health problem. This study was designed to establish bone mineral density (BMD) reference databases for central southern Chinese men at multiple skeletal...
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Article
Establishment of BMD reference curves at different skeletal sites in women, using a Cartesian coordinate numeration system
The BMD reference curve is the reference value used for diagnosing osteoporosis and assessing bone mass changes. Its accuracy would affect the correctness of T -score and Z -score values and thus the reliability ...
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Article
Comparison of spine and femur reference data in native Chinese women from different regions of China
The aim of this study is to explore the differences of BMD reference curves at various skeletal sites among Chinese women from different regions of China and to investigate the feasibility of establishing a un...
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Article
Application of micro-ct assessment of 3-d bone microstructure in preclinical and clinical studies
As the mechanical competence of trabecular bone is a function of its apparent density and 3-D distribution, assessment of 3-D trabecular structural characteristics may improve our ability to understand the pat...
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Article
Effects of 17 β-estradiol on the expression of interstitial collagenases-8 and −13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells
Estrogen plays an important role in maintaining normal bone metabolism via the direct or indirect regulation of bone cells. Osteoblastic cells, as the target cells of estrogen, can secrete multiple matrix metallo...
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Article
Determination of age-specific bone mineral density and comparison of diagnosis and prevalence of primary osteoporosis in Chinese women based on both Chinese and World Health Organization criteria
The aim of this study was to determine age-specific bone mineral density (BMD) at various skeletal regions in a native Chinese reference population, and to explore the differences in the diagnosis of primary o...
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Article
Microcracks: an alternative index for evaluating bone biomechanical quality
To investigate microcracks as a potential index of bone biomechanical quality in rats, 98 Sprague-Dawley (SD) rats, 10 months old, were used. Eight rats were killed at the beginning of the study, to serve as b...
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Article
Establishment and evaluation of bone mineral density reference databases appropriate for diagnosis and evaluation of osteoporosis in Chinese women
This study was designed to establish Bone Mineral Density (BMD) Reference Databases for multiple skeletal sites appropriate for the diagnosis and evaluation of osteoporosis (OP) in Chinese women. We recruited...
