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Precessing jet nozzle connecting to a spinning black hole in M87
The nearby radio galaxy M87 offers a unique opportunity to explore the connections between the central supermassive black hole and relativistic jets. Previous studies of the inner region of M87 revealed a wide...
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Article
Open AccessA ring-like accretion structure in M87 connecting its black hole and jet
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure...
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Open AccessEvolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance
It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis of 163 matched blo...
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Open AccessA cross-sectional study of Chinese women facial skin status with environmental factors and individual lifestyles
Geographical, environmental and pollution conditions affect facial skin health, but their effects on skin appearance have not been elucidated. This study aimed to describe the skin barrier and skin tone charac...
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Article
Structural basis for the tethered peptide activation of adhesion GPCRs
Adhesion G-protein-coupled receptors (aGPCRs) are important for organogenesis, neurodevelopment, reproduction and other processes1–6. Many aGPCRs are activated by a conserved internal (tethered) agonist sequence ...
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Open AccessStructural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfam...
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Article
STING controls nociception via type I interferon signalling in sensory neurons
The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cel...
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Article
Open AccessIon adsorption-induced reversible polarization switching of a van der Waals layered ferroelectric
Solid-liquid interface is a key concept of many research fields, enabling numerous physical phenomena and practical applications. For example, electrode-electrolyte interfaces with electric double layers have ...
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Article
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available1–3. Here we report that glucocorticoid stress hormones activate...
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Article
Open AccessChloroplast genomes elucidate diversity, phylogeny, and taxonomy of Pulsatilla (Ranunculaceae)
Pulsatilla (Ranunculaceae) consists of about 40 species, and many of them have horticultural and/or medicinal value. However, it is difficult to recognize and identify wild Pulsatilla species. Universal molecular...
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Article
Open AccessEvaluation of left ventricular strain in patients with arrhythmia based on the 3T MR temporal parallel acquisition technique
Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic...
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Open AccessReference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects
Curvature-based three-dimensional cardiovascular magnetic resonance (CMR) allows regional function characterization without an external spatial frame of reference. However, introduction of this modality into c...
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Article
Open AccessRational design of crystalline two-dimensional frameworks with highly complicated topological structures
Constructing two-dimensional (2D) polymers with complex tessellation patterns via synthetic chemistry makes a significant contribution not only to the understanding of the emergence of complex hierarchical sys...
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Article
Open AccessGeneralized Mechanism of Field Emission from Nanostructured Semiconductor Film Cathodes
Considering the effect of both the buffer layer and substrate, a series of ultrathin multilayered structure cathodes (UTMC) is constructed to simulate the field emission (FE) process of nanostructured semicond...
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Article
Open Accessβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duratio...
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Open AccessEffect of heavy haze and aerosol pollution on rice and wheat productions in China
In China, regional haze pollution is a serious environmental problem. The impact on ecosystem, however, is not clearly understood. This study investigates the effect of regional haze pollution on the yields of...
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Open AccessA low cost, green method to synthesize GaN nanowires
The synthesis of gallium nitride nanowires (GaN NWs) by plasma enhanced chemical vapor deposition (PECVD) are successfully demonstrated in this work. The simple and green synthesis route is to introduce galliu...
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Article
Open AccessHistidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration
The formation of glial scar impedes the neurogenesis and neural functional recovery following cerebral ischemia. Histamine showed neuroprotection at early stage after cerebral ischemia, however, its long-term ...
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Open AccessRapid preparation of rare ginsenosides by acid transformation and their structure-activity relationships against cancer cells
The anticancer activities of ginsenosides are widely reported. The structure-activity relationship of ginsenosides against cancer is not well elucidated because of the unavailability of these compounds. In thi...