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Article
Open AccessTMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...
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Article
Open AccessStructure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia
Transient receptor potential vanilloid 1 (TRPV1) ion channel is a classic analgesic target, but antagonists of TRPV1 failed in clinical trials due to their side effects like hyperthermia. Here we rationally en...
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Article
Specialized Microglia Resolve Neuropathic Pain in the Spinal Cord
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Article
Resolution of Inflammatory Pain by Endogenous Chemerin and G Protein-Coupled Receptor ChemR23
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Article
The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain
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Article
Open AccessInterferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions
It is well known that interferons (IFNs), such as type-I IFN (IFN-α) and type-II IFN (IFN-γ) are produced by immune cells to elicit antiviral effects. IFNs are also produced by glial cells in the CNS to regula...
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Article
Open Accessβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duratio...
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Article
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade
Toll-like receptor 5 (TLR5) expression is found to be enriched in mouse dorsal root ganglion (DRG) A-fiber neurons known to mediate mechanical allodynia, a form of chronic neuropathic pain. Selective silencing...
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Article
Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter
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Article
Emerging targets in neuroinflammation-driven chronic pain
Chronic pain cannot be effectively treated using current drugs such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs).
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Article
Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury
Accumulating evidence indicates that activation of spinal cord microglia plays an important role in the genesis of neuropathic pain. Resolvin E1 (E1) is derived from omega-3 polyunsaturated fatty acid and exhi...
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Article
Open AccessAcute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
Activation of spinal cord glial cells such as microglia and astrocytes has been shown to regulate chronic opioid-induced antinociceptive tolerance and hyperalgesia, due to spinal up-regulation of the proinflam...
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Article
Toll-like receptor 7 mediates pruritus
Liu and colleagues report that toll-like receptor 7 (TLR7), which is typically thought to be expressed in immune cells and to function to regulate innate immunity, is expressed and acts in C-fiber primary sens...
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Article
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid alleviate inflammatory pain in patients. Ru-Rong Ji and his colleagues find that the resolvins RvE1 and RvD1, which are derived from omega...
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Article
Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
Treatment of neuropathic pain, triggered by multiple insults to the nervous system, is a clinical challenge because the underlying mechanisms of neuropathic pain development remain poorly understood1,2,3,4. Most ...
