5 Result(s)
-
Article
Open AccessA role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange fact...
-
Article
Open AccessUpregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain
Cervical radiculopathy represents aberrant mechanical hypersensitivity. Primary sensory neuron’s ability to sense mechanical force forms mechanotransduction. However, whether this property undergoes activity-d...
-
Article
Open Accessβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duratio...
-
Article
Open AccessGastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation
Tissue injury is known to produce inflammation and pain. Synaptic potentiation between peripheral nociceptors and spinal lamina I neurons has been proposed to serve as a trigger for chronic inflammatory pain. ...
-
Article
Open AccessPresynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plas...
