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  1. Article

    Erratum: Targeting the TGFβ signalling pathway in disease

    Nature Reviews Drug Discovery 11, 790–811 (2012) On page 7 of the main text, LY2382770 was incorrectly referred to as a pan-TGFβ ligand-specific blocking antibody; it is a TGFβ1 ligand-selective blocking antib...

    Rosemary J. Akhurst, Akiko Hata in Nature Reviews Drug Discovery (2012)

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    Targeting the TGFβ signalling pathway in disease

  3. Transforming growth factor-β (TGFβ) has pleiotropic effects on many cell types in vivo, mediated via multiple signalling pathways — canonical and non-canonical

    4. Rosemary J. Akhurst, Akiko Hata in Nature Reviews Drug Discovery (2012)

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    The paradoxical TGF-β vasculopathies

    Two new studies show that haploinsufficiency for TGFB2 causes a familial syndrome of thoracic aortic aneurysms and dissections with other clinical features that overlap the Marfan, Loeys-Dietz spectrum of syndrom...

    Rosemary J. Akhurst in Nature Genetics (2012)

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    Taking thalidomide out of rehab

    Thalidomide, a drug reviled in the 1960s for its teratogenic effects, has been revived in recent years for cancer and leprosy therapy. A study now finds another use for this drug in vascular disease, providing...

    Rosemary J Akhurst in Nature Medicine (2010)

  6. Article

    Transforming growth factor-β in breast cancer: too much, too late

    The contribution of transforming growth factor (TGF)β to breast cancer has been studied from a myriad perspectives since seminal studies more than two decades ago. Although the action of TGFβ as a canonical tu...

    Mary Helen Barcellos-Hoff, Rosemary J Akhurst in Breast Cancer Research (2009)

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    A sweet link between TGFβ and vascular disease?

    Mutations in SCL2A10, encoding a glucose transporter, result in arterial tortuosity syndrome, indicating a link between glucose metabolism and angiopathic changes. Intriguingly, some of the phenotypic effects of

    Rosemary J Akhurst in Nature Genetics (2006)

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    TGFβ signaling in health and disease

    Inactivating mutations in TGFBR2, encoding the transforming growth factor-β (TGFβ) type 2 receptor, may account for up to 10% of cases of Marfan syndrome. This finding has implications for a wider spectrum of dis...

    Rosemary J Akhurst in Nature Genetics (2004)

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    TGF-β signaling in tumor suppression and cancer progression

    Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorig...

    Rik Derynck, Rosemary J. Akhurst, Allan Balmain in Nature Genetics (2001)

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    Map** of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

    The transforming growth factor β1 (TGFβ1) signalling pathway1,2 is important in embryogenesis3 and has been implicated in hereditary haemorrhagic telangiectasia (HHT)4,5, atherosclerosis6,7, tumorigenesis8,9 and ...

    Mortaza Bonyadi, Sarah A.B. Rusholme, Frances M. Cousins, Helen C. Su… in Nature Genetics (1997)