-
Article
The role of 18F-FAZA PET/CT in detecting lymph node metastases in renal cell carcinoma patients: a prospective pilot trial
The accurate detection of nodal invasion is an unmet need in the clinical staging of renal cancer. Positron emission tomography (PET) with 18F-fluoroazomycin arabinoside (18F-FAZA), a hypoxia specific tracer, ...
-
Article
Open AccessA retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the ...
-
Article
Open AccessA HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a sub-type of acute myeloid leukemia (AML) characterized by a block of myeloid differentiation at the promyelocytic stage and the predominant t(15:17) chromosomal transloc...
-
Article
Hallmarks of triple negative breast cancer emerging at last?
Triple negative breast cancers (TNBC) are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 (ERBB2 or NEU) receptors. Recent evidence shows...
-
Article
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction
Depletion of ribosomal protein S6 leads to upregulation of p53 and cell cycle arrest. Surprisingly, p53 induction is not due to nucleolar disruption and Mdm2 inhibition, but rather the selective translation of...
-
Article
PML targeting eradicates quiescent leukaemia-initiating cells
The existence of a small population of ‘cancer-initiating cells’ responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia...
-
Article
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
PML is a tumour suppressor protein that typically localizes to and is necessary for the formation of nuclear macromolecular structures called promyelocytic leu...
-
Article
PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR
Loss of the promyelocytic leukaemia (PML) tumour suppressor has been observed in several human cancers. The tumour-suppressive function of PML has been attributed to its ability to induce growth arrest, cellul...
-
Article
Role of nucleophosmin in embryonic development and tumorigenesis
Nucleophosmin is an oestrogen-regulated nucleolar protein that has been implicated in a number of cancers including myelodysplastic syndromes (MDS), a group of diseases characterized by overproduction of blood...
-
Article
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation1,2 and Chk2-dependent phosphorylation, in the...
-
Article
Role of PML and the PML-nuclear body in the control of programmed cell death
PML is a tumor suppressor implicated in leukemia and cancer pathogenesis. PML epitomizes a multiprotein nuclear structure, the PML-nuclear body (PML-NB), whose proper formation and function depends on PML. Stu...
-
Article
The nucleolus: at the stem of immortality
A nucleolar protein, nucleostemin, is now implicated in the control of stem and cancer cell proliferation. Nucleostemin may modulate p53 function through shuttling between the nucleolus and the nucleoplasm.
-
Article
Modelling haematopoietic malignancies in the mouse and therapeutical implications
Modelling human disease in the mouse has become an essential activity in biomedical research in order to unravel molecular mechanisms underlying pathological conditions as well as to determine in vivo the consequ...
-
Article
Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
Members of the cdc25 family are protein phosphatases that play pivotal roles in cell cycle progression. Cdc25A has been shown to be a critical regulator of the G1/S transition of mammalian cells and to be a myc-t...
-
Article
Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene
Although apoptosis can be induced by the enforced expression of exogenously introduced c-myc genes, it is not clear whether overexpression resulting from the amplification of the resident c-myc gene in tumor cell...
-
Article
Poly(ADP-ribose) synthesis: a useful parameter for identifying apoptotic cells
Cell death by apoptosis was analysed in HeLa cells either treated with the antitumoral drug bleomycin or depleted of growth factors by long-term culture without medium change. The interference of apoptosis wit...
