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Article
Open AccessCirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways
Postmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast formation and function. Targeting osteoclast differentiation and activity can modulate bone resorption and allevia...
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Article
Open AccessAssociation between maternal health service utilization and under-five mortality rate in China and its provinces, 1990–2017
The United Nations (UN) Sustainable Development Goal − 3.2 aims to eliminate all preventable under-five mortality rate (U5MR). In China, government have made efforts to provide maternal health services and red...
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Article
Open AccessThe role of military service in preventing depression in China: evidence from a nationally representative longitudinal survey
Despite recognition in the West that military veterans experience more mental health issues than the general population, little research has focused on this subject in China. This study examined the associatio...
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Article
Open AccessIdentification of hub genes and therapeutic drugs in osteonecrosis of the femoral head through integrated bioinformatics analysis and literature mining
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effect...
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Article
Open AccessSmall-scale spatiotemporal epidemiology of notifiable infectious diseases in China: a systematic review
The prevalence of infectious diseases remains one of the major challenges faced by the Chinese health sector. Policymakers have a tremendous interest in investigating the spatiotemporal epidemiology of infecti...
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Article
Open AccessPartial two-stage exchange: an alternative method for infected total hip arthroplasty
Total two-stage exchange is commonly used in clinical practice as a treatment for infected total hip arthroplasty (THA); however, this approach involves considerable limitations, including significant bone los...
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Article
Open AccessWomen’s cancers in China: a spatio-temporal epidemiology analysis
Women's cancers, represented by breast and gynecologic cancers, are emerging as a significant threat to women's health, while previous studies paid little attention to the spatial distribution of women's cance...
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Article
Open AccessExtracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway
Interleukin (IL)-37, a pivotal anti-inflammatory cytokine and a fundamental inhibitor of innate immunity, has recently been shown to be abnormally expressed in several autoimmune-related orthopedic diseases, i...
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Article
Open AccessA systematic review of depression and anxiety in medical students in China
Medical students in China face severe depression and anxiety because of their difficult circumstances, such as the long length of schooling, academic pressure, and the stress of clinical practice. Although the...
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Article
Open AccessA descriptive analysis of the Spatio-temporal distribution of intestinal infectious diseases in China
Intestinal infectious diseases (IIDs) have caused numerous deaths worldwide, particularly among children. In China, eight IIDs are listed as notifiable infectious diseases, including cholera, poliomyelitis, dy...
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Article
Open AccessNon-contemporaneous bilateral stem fractures occurring after staged bilateral hip revision using extensively porous-coated cylindrical femoral stems: a case report
Distally fixed cylindrical femoral stems extensively coated with porous materials are widely used in revision and total hip arthroplasty surgeries. Stem fracture is an uncommon complication; few case reports h...
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Article
Open AccessDetecting the priority areas for health workforce allocation with LISA functions: an empirical analysis for China
Health workforce misdistribution leads to severe inequity and low-efficiency in health services in the develo** countries. Targeting at China, this research aims to reveal, visualize and compare the geograph...
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Article
Open AccessKnockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway
Forkhead box protein A2 (FOXA2) is a core transcription factor that controls cell differentiation and may have an important role in bone metabolism. However, the role of FOXA2 during osteogenic differentiation...
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Article
Solitary plasmacytoma of bone and extramedullary plasmacytoma
Among plasma cell disorders, solitary plasmacytoma (solitary-plasmacytoma of bone, SPB and extramedullary plasmacytoma, EMP) is rare as compared with mulitiple myeloma (MM). Furthermore, the relationship betwe...
